[Morphological criteria of chronic opisthorchiasis treatment].

Morphological examinations of the liver in chronic opisthorchiasis have both diagnostic and prognostic importance. Significant lowering of the number of cells of the portal tract inflammatory infiltrate per area unit (1 mmI), decreased number of neutrophilic and eosinophilic leukocytes, elevated count of monocytes are not only morphological markers of successful dehelminthization but they also reflect objective improvement of the liver state this being an absolute criterion of effective therapy.

[Surveillance of acute flaccid paralysis in Belarus].

The ten-years experience of acute flaccid paralysis (AFP) surveillance in Belarus has been summarized. Among 456 AFP cases reported from 1996 to 2005, 11 were classified as vaccine-associated paralytic poliomyelitis (VAPP), 445--as non-polio AFP. The risk of VAPP for the period 1996-2001 was 1 case per 745,000 used doses of oral poliovaccine (OPV).

[Administration of ehf-therapy for rehabilitation of locomotor diseases].

Noise EHF radiation under low-frequency (10 Hz) modulation both in monovariant and in combination with spinal tractions promotes regression of neuro-orthopedic disorders. Good effects were achieved due to improvement of zonal hemodynamics, conditions of functioning of the neuromuscular and locomotor system of the spine and limbs, favourable shifts in biochemical and autonomic status of patients with lumbar osteochondrosis and osteoarthrosis.

[The immunological efficacy of one, two and three inoculations against diphtheria in adults].

The outbreak of diphtheria in the Republic of Belarus developed in the presence of a sharp deficiency of immunity among the population aged 35 years and over. In connection with a higher initial immunity level resulting from vaccination made in one injection the minimum antibody level (> or = 0.01 I.

[The effect of electromagnetic radiation in the millimeter range on the development of disorders in the liver induced by ether anesthesia (experimental research)].

Rat experiments with ether anaesthesia (EA) indicate that EA induces enlargement of hepatic sinusoids, stasis and perivascular edema of the triad vessels and other changes in the liver. Right hypochondrium exposure to electromagnetic waves (4.76-5.

[Effect of peptides, isolated from the tracheal mucosa, on alveolar macrophages and the nature of the course of fibrosing alveolitis in the rat].

Rats with bleomycin-induced pulmonary fibrosis were treated with a complex of low-molecular weight peptides isolated from the tracheal mucosa (PTM). Cytological examinations of bronchoalveolar lavage fluid from the animals receiving PTM revealed increases in the number of alveolar macrophages (AM) as compared to that in saline-treated rats. The AM obtained from PTM-treated animals also showed an enhanced phagocytic activity, as well as increased superoxide anion production when stimulated with the opsonized zymosan.

[The protective effect of peptides from the thymus and tracheal mucosa in an experimental respiratory influenzal infection].

To evaluate the possible antiviral activity of a number of peptide bioregulators, an acute influenza infection was induced in developing chick embryos and mice. Four peptide preparations were used: two medicinal peptide preparations of the thymus (thymalin and thymogen) and peptide preparations obtained from the tracheal mucosa (PTM) and lung parenchyma (PLP) of calves according to the technology used for obtaining thymalin. For control, remantadin (for type A virus) and adapromin (for type B virus) were used as antiviral remedies.

[Effect of peptides of the tracheal mucosa and vascular wall in acute hyperoxic lung injury].

It was demonstrated that peptides of the tracheal mucosa (PTM) and peptides of the vascular wall (PVW) produce a certain protective effect in hyperoxic lung injury. The peptides, (PTM to a greater measure) prolonged the survival of mice and inhibited the dynamics of the growth of the lung coefficient in rats. PTM reduced the formation of malonic dialdehyde and increased the activity of glucose-6-phosphate dehydrogenase in the lungs.

[Relaxant effects of oligopeptides isolated from the tracheal mucosa and pulmonary parenchyma on the smooth muscle of isolated rat trachea].

Relaxant effect of oligopeptides extracted from tracheal mucosa (PTM), lung parenchyma (PLP), aortal wall (PAW) and thymic gland (PTG) was investigated using acetylcholine-induced constriction of tracheal strips. Time of 50 percent relaxation of constricted strips treated with saline, atropine or peptides was measured. Both PTM and PLP in concentrations 10(-6)-10(-3) g/ml accelerated relaxation in dose-dependent manner, however this effect was less prominent compared with atropine.

[The effect of thymalin on biochemical and immunological indices of lymphocyte differentiation and functional activity].

Polypeptide preparation thymalin obtained from thymus was found to normalize the LDH isoenzyme spectrum and cyclase system in lymphocytes of patients. Thymalin contributed also to expression of differentiation antigens on T-lymphocytes surface. As a result of this functional activity of T-lymphocytes was restored, which correlated with improvement of the patients clinical state.

[Participation of the cyclase system in the molecular mechanisms of differentiation control of immunocompetent cells].

The effects of polypeptide thymic and bone marrow factors on the cyclase system of rat thymus and spleen lymphocytes were studied. It was shown that the induction of maturation of rat T-lymphocyte precursors into immunocompetent T-cells under effects of the thymic factor is accompanied by the activation of the adenylate cyclase system and the elevation of the cAMP/cGMP ratio. The observed increase in the cGMP level in splenic lymphocytes suggests the presence of cAMP- and cGMP-dependent steps of in the reaction of T-lymphocyte maturation.

[Effect of thymic polypeptide factor on the cyclic nucleotide system of immunocompetent cells].

Thyramine, a polypeptide factor from thymus, at wide range of concentrations increased the cAMP content in rat thymocytes. Increase in the cAMP content was less distinct in spleen lymphoid cells. Thyramine decreased the cGMP content in thymocytes; minimal nucleotide level was found within 15 min of incubation.