The effect of continuous positive airway pressure therapy on early atherosclerosis in patients with severe obstructive sleep apnea-hypopnea syndrome.

Purpose: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is the most common sleep-related breathing disorder. Longer term, repeated episodes of hypercapnia and hypoxemia during sleep are associated with inflammatory and atherosclerosis-related factors. The aim of this study was to explore the effect of continuous positive airway pressure (CPAP) therapy on cerebral vasoreactivity and early atherosclerosis in patients with severe OSAHS.

Potential and real dangers of the chemical warfare agents use during the full-scale invasion into Ukraine.

Objective: Aim: To analyze modern threats of the use of chemical warfare agents on the line of contact during the full-scale invasion into Ukraine.

Patients And Methods: Materials and Methods: The study was carried out with the use of theoretical methods (information retrieval, analytical, descriptive, generalization, system analysis and information synthesis) and the construction of trends with the identification of the coefficient of determination.

Results: Results: Most of damage cases of the military men of the Armed Forces of Ukraine were caused by the enemy's use of such groups of chemical warfare agents with an irritating effect as lacrimators and sternites, more specifically K-51 grenades with chloropicrin (PS) and 2-chlorobenzalmalononitrile (CS), RGR grenade with 2-chlorobenzalmalononitrile (CS) and RG-Vo (862-3-23) grenades with chloroacetophenone (CN).

A CASE REPORT OF EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS.

Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Charg-Strauss syndrome or allergic granulomatous angiitis, is defined as a systemic vasculitis identified by the presence of allergic rhinitis and/or asthma, correlated with the presence of marked eosinophilia in the peripheral blood, eosinophilic infiltration of various organs with extensive areas of necrosis, eosinophilic, giant cell vasculitis of vessels of small and medium caliber, as well as perivascular and interstitial necrotizing granulomas. The frequency is 10 - 14 cases per million in the adult population. The average time interval from the onset of the disease to establishing the diagnosis is 49.

National Cancer Institute Collaborative Workshop on Shaping the Landscape of Brain Metastases Research: challenges and recommended priorities.

Brain metastases are an increasing global public health concern, even as survival rates improve for patients with metastatic disease. Both metastases and the sequelae of their treatment are key determinants of the inter-related priorities of patient survival, function, and quality of life, mandating a multidimensional approach to clinical care and research. At a virtual National Cancer Institute Workshop in September, 2022, key stakeholders convened to define research priorities to address the crucial areas of unmet need for patients with brain metastases to achieve meaningful advances in patient outcomes.

Mercury and amino acid content relations in northern pike (Esox lucius) in subarctic lakes along a climate-productivity gradient.

Mercury is a highly toxic element for consumers, but its relation to amino acids and physiology of wild fish is not well known. The main aim of this study was to evaluate how total mercury content (THg) of northern pike (Esox lucius) is related to amino acids and potentially important environmental and biological factors along a climate-productivity gradient of ten subarctic lakes. Linear regression between THg and sixteen amino acids content [nmol mg dry weight] from white dorsal muscle of pike from these lakes were tested.

Photovoice Exploration of Frontline Nurses' Experiences During the COVID-19 Pandemic.

Background: The current COVID-19 global pandemic has had a profound impact on the health care system and on the physical and psychological well-being of nurses. Previous pandemics have led to nurses leaving the profession. Therefore, it is important that we hear the voices of nurses who experienced the pandemic on the frontlines to influence future planning and policy development.

The Effect of Long-Term Storage on .

It was established that when stored for many years (10-13 years) in low-temperature conditions (3°C), without sub-culture on a nutrient medium, grew as visible colonies along the line of inoculation. However, due to long-term storage in conditions of low temperature (3°C) morphology of mycobacteria differed significantly from initial cultures formed by rod-shaped bacteria. Some of them became pigment-forming and smooth on the surface.

Environmental and biological factors are joint drivers of mercury biomagnification in subarctic lake food webs along a climate and productivity gradient.

Subarctic lakes are getting warmer and more productive due to the joint effects of climate change and intensive land-use practices (e.g. forest clear-cutting and peatland ditching), processes that potentially increase leaching of peat- and soil-stored mercury into lake ecosystems.

COMPARATIVE HYGIENIC ASSESSMENT OF PESTICIDES BEHAVIOR IN SOIL IN INTENSIVE GRAIN FARMING TECHNOLOGIES.

Objective: The aim: Was the comparative hygienic evaluation of the pesticide behavior in the soil after application on cereals.

Patients And Methods: Material and methods: Methods of full-scale in-field hygienic experiment, high-performance liquid (HPLC), gas-liquid (GLC), thin-layer chromatography, statistical, bibliography were used in the research.

Results: Results: Data on the detailed conditions and land parcels treated with studied pesticide formulation and its a.

Advancement of a standardised enteral feeding protocol in functional single ventricle patients following stage I palliation using cerebro-somatic near-infrared spectroscopy.

Introduction: Infants with single ventricle following stage I palliation are at risk for poor nutrition and growth failure. We hypothesise a standardised enteral feeding protocol for these infants that will result in a more rapid attainment of nutritional goals without an increased incidence of gastrointestinal co-morbidities.

Materials And Methods: Single-centre cardiac ICU, prospective case series with historical comparisons.

Acute steroid myopathy: a highly overlooked entity.

Background: Myopathy in patients being treated with corticosteroids is known primarily among chronically treated patients or in critically ill and mechanically ventilated patients receiving corticosteroids, often in high doses.

Aim: To highlight the entity of acute, early onset corticosteroid-treatment-associated myopathy and its characteristics.

Design And Methods: Reporting our experience with four patients and reviewing all published reports of myopathy developing ≤14 days of initiating corticosteroid-treatment.

Quantitative EEG in obstructive sleep apnea syndrome: a review of the literature.

Obstructive sleep apnea syndrome (OSAS) is characterized by the recurrent cessation (apnea) or reduction (hypopnea) of airflow due to the partial or complete upper airway collapse during sleep. Respiratory disturbances causing sleep fragmentation and repetitive nocturnal hypoxia are responsible for a variety of nocturnal and daytime complaints of sleep apnea patients, such as snoring, daytime sleepiness, fatigue, or impaired cognitive functions. Different techniques, such as magnetic resonance imaging, magnetic resonance spectroscopy, and positron emission tomography, are used to evaluate the structural and functional changes in OSAS patients.

Predictors of Symptomatic Vasospasm After Subarachnoid Hemorrhage: A Single Center Study of 457 Consecutive Cases.

Aim: We set forth to identify predictors of symptomatic vasospasm in patients with subarachnoid hemorrhage (SAH).

Material And Methods: We used multivariate logistic regression analysis of the prospective, hospital based, single center register of the Department of Neurosurgery, University of Debrecen, Hungary. Evaluated patients' characteristics were: sex, age, Hunt-Hess grade on admission, location of aneurysm, thickness of blood clot on initial CT scan (Fisher grade), hypertension.

[CORRECTION OF BILE FLOW CHARACTERISTICS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE IN COMBINATION WITH HYPERURICEMIA].

Basis on study through integrated comparative assessment of clinical, biochemical survey data revealed that in patients with impaired metabolism of uric acid in a greater percentage of common biliary sludge, a violation of the rheological properties of bile, a violation of cholate-cholesterol ratio index, which indicates an increased risk of bile stones. The study found that despite the high levels of uric acid there is a violation of the spectrum of bile acids, cholic and deoxycholic growth acid reduction taurocholic acid. Thus, application of ursodeoxycholic acid, rosuvastatin and allopurinol in these study patients with NAFLD dosages in combination with hyperuricemia improves the clinical symptoms and normalization of biochemical parameters and normalizes the spectrum of biliary acids.

Large outbreak of Legionnaires' disease and Pontiac fever at a military base.

We investigated a mixed outbreak of Legionnaires' disease (LD) and Pontiac fever (PF) at a military base to identify the outbreak's environmental source as well as known legionellosis risk factors. Base workers with possible legionellosis were interviewed and, if consenting, underwent testing for legionellosis. A retrospective cohort study collected information on occupants of the buildings closest to the outbreak source.

Etanercept-associated transient bone marrow aplasia: a review of the literature and pathogenetic mechanisms.

A patient with rheumatoid arthritis presented with increasing fatigue, fever, gingival bleeding, and petechial rash. Her symptoms started 1 week after the first injection of etanercept (Enbrel). Her only other medications (methotrexate and hydroxychloroquine) had been unchanged for years.

Monitoring of anti-Xa in pregnant patients with mechanical prosthetic valves receiving low-molecular-weight heparin: peak or trough levels?

Objectives: We hypothesized that the guideline-recommended peak anti-Xa levels for pregnant women with mechanical prosthetic heart valves (MPHVs) receiving adjusted dose low-molecular-weight heparin (LMWH) are associated with subtherapeutic trough levels and consequently with an inadequate level of anticoagulation.

Background: Low-molecular-weight heparin is often used for anticoagulation in pregnant women including those with MPHV. American College of Cardiology/American Heart Association guidelines recommend monitoring of plasma anti-Xa factor peak levels and adjustment of the dose to achieve peak levels of 0.

Legionnaires' disease case-finding algorithm, attack rates, and risk factors during a residential outbreak among older adults: an environmental and cohort study.

Background: During a Legionnaires' disease (LD) outbreak, combined epidemiological and environmental investigations were conducted to identify prevention recommendations for facilities where elderly residents live independently but have an increased risk of legionellosis.

Methods: Survey responses (n = 143) were used to calculate attack rates and describe transmission routes by estimating relative risk (RR) and 95% confidence intervals (95% CI). Potable water collected from five apartments of LD patients and three randomly-selected apartments of residents without LD (n = 103 samples) was cultured for Legionella.

Identification of legionella in the environment.

Legionella is ubiquitous in freshwater systems worldwide and can also be found in soil. Legionellosis may be caused by inhalation of aerosolized water or soil particles containing Legionella. Isolation of Legionella from the environment is an essential step in outbreak investigation and may also be performed within the context of a hazard analysis and control risk management plan.

Primary amebic meningoencephalitis deaths associated with sinus irrigation using contaminated tap water.

Background: Naegleria fowleri is a climate-sensitive, thermophilic ameba found in the environment, including warm, freshwater lakes and rivers. Primary amebic meningoencephalitis (PAM), which is almost universally fatal, occurs when N. fowleri-containing water enters the nose, typically during swimming, and N.