Publications by authors named "Koyeli Das"

Heavy metals (HMs) pollution is a pervasive environmental issue needs significant attention through bioremediation. Present study investigated the potentiality of Microbial-mediated Cerium Carbonate Precipitation (MMCCP) in simultaneous removal of HMs (Cr, Pb, and Cu) using different cellular concentration of Sporosarcina pasteurii. Results from SEM analysis revealed formation of spherical and rod-like structures (∼112nm), and finally XRD and FTIR confirmed the formation of high-purity crystalline CeCOOH with surface-bound hydroxyl groups and CO ions, indicating successful cerium incorporation and formation in CeCOOH.

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Mangroves, essential coastal ecosystems, are threatened by human-induced Potentially-toxic-elements (PTEs) pollution. This study analyzed PTEs distribution, phytoremediation potential, and rhizosphere microbial communities in Taiwan's Xinfeng mangrove forest. Significant variations in physicochemical and PTEs concentrations were observed across adjacent water bodies, with moderate contamination in the river, estuary, and overlying water of mangroves sediment.

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Article Synopsis
  • The text discusses the ecological disruption caused by civilization, highlighting the issue of excess fluoride in groundwater and its link to global health problems like "Fluorosis."
  • It reviews various defluoridation methods, emphasizing biosorption as an economical and eco-friendly option but notes its limited commercialization, indicating a need for more research.
  • The article provides insights into the chemical properties and preparation of agro-based adsorbents, factors affecting fluoride removal, and recommends strategies to enhance scalability and effectiveness in real-world applications.
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  • Improper disposal practices have led to environmental issues like contamination from heavy metals and radioactive elements, necessitating innovative and sustainable remediation strategies such as Microbially Induced Carbonate Precipitation (MICP).
  • MICP uses urease-producing microorganisms to convert urea into ammonium and carbon dioxide, raising pH levels and promoting carbonate precipitation to remove contaminants effectively.
  • Although MICP shows promise in cost-efficiency and pollutant removal compared to traditional methods, challenges such as large-scale application and contaminant release need addressing, with future research focusing on enhancing its effectiveness and potential for long-term environmental benefits.
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With the growing age of human civilization, industrialization has paced up equally which is followed by the innovation of newer concepts of science and technology. One such example is the invention of engineered nanoparticles and their flagrant use in widespread applications. While ENPs serve their intended purposes, they also disrupt the ecological balance by contaminating pristine aquatic ecosystems.

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  • Dual localization refers to proteins being found in multiple compartments of the cell, with about a third of mitochondrial proteins also having roles outside of mitochondria, suggesting an evolutionary benefit.
  • The study used two methods to identify additional proteins with primarily non-mitochondrial functions that are still found in mitochondria, discovering 280 new candidates with unique properties.
  • A specific focus on the Triose-phosphate DeHydrogenases family revealed that their presence in mitochondria is crucial for mitochondrial function, offering new insights into the role of eclipsed proteins in health and disease.
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Heavy metal pollution of water is a burning issue of today's world. Among several strategies involved for heavy metal remediation purpose, biomineralization has shown great potential. Of late, research has been focused on developing effective mineral adsorbents with reduced time and cost consumption.

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  • Mitochondria, essential for energy production and metabolic functions, release vesicles (MDVs) independent of usual fission, suggesting an important role in organelle communication.* -
  • The isolated MDVs are about 100 nm in size and contain proteins, particularly ATP synthase subunits, indicating a specialized function.* -
  • These MDVs are capable of generating ATP and may help restore energy in mitochondria that are lacking ATP, highlighting a potential new mechanism of communication between organelles.*
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Ubiquitination is a critical type of post-translational modification in eukaryotic cells. It is involved in regulating nearly all cellular processes in the cytosol and nucleus. Mitochondria, known as the metabolism heart of the cell, are organelles that evolved from bacteria.

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  • Metal nanoparticles are toxic, which has led to increasing research into green nanoparticle synthesis to enhance their safety and effectiveness in environmental and clinical applications.
  • The article discusses the various factors influencing the synthesis of green nanoparticles, including different biosurfactants and methods that promote eco-friendly production.
  • Advances in using biological strains for nanoparticle production are highlighted as a promising and cost-effective approach for future medical research.
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Inclusion complexation is one of the best strategies for developing a controlled release of a toxic drug without unexpected side effects from the very beginning of the administration to the target site. In this study, three benzimidazolium based ionic liquids (ILs) having bromide anion and cation bearing long alkyl chains, hexyl- ([CCFBim]Br), octyl- ([CCFBim]Br), and decyl- ([CCFBim]Br) were designed and synthesized as antibacterial drugs. Inclusion complexes (ICs) of studied ILs have been prepared by the combination of β-cyclodextrin (β-CD), considering these conjugations should enhance the benignity of ILs and make them potential candidates for the controlled drug release.

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Class-II fumarases (fumarate hydratase, FH) are dual-targeted enzymes occurring in the mitochondria and cytosol of all eukaryotes. They are essential components in the DNA damage response (DDR) and, more specifically, protect cells from DNA double-strand breaks. Similarly, the gram-positive bacterium class-II fumarase, in addition to its role in the tricarboxylic acid cycle, participates in the DDR.

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Objective: Tobacco consumption is one of the major etiological factors for oral cancer, but it also develops in non-tobacco users, with unknown etiologies. Cellular models for tobacco associated oral cancer are available, however; reports of cellular models for studying non-tobacco associated oral cancer are limiting. We report here the establishment and characterization of two novel buccal mucosal cancer cell lines 'GBC02' and 'GBC035' derived from non-tobacco users.

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  • The study investigates how two drugs, phenylephrine hydrochloride (PEH) and synephrine (SNP), interact with cyclodextrins (α and β-CD) to form inclusion complexes using various physicochemical methods.
  • Techniques like conductance, surface tension, UV-Vis spectroscopy, and spectrofluorometry confirm a 1:1 stoichiometry and establish the stability of these complexes through calculated association constants.
  • The research highlights the cytotoxic assessment of these inclusion complexes, demonstrating non-toxic behavior and suggesting their potential for improved drug delivery systems without requiring any chemical modifications.
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The interface between pyrrolidinium-based ionic liquid, i.e., 1-ethyl-1-methylpyrrolidinium bromide, with β-cyclodextrin and 18-crown-6 solution have been compared and explored by means of density, viscosity, refractive index, electrical conductance and surface tension, FTIR, H nuclear magnetic resonance, 2D ROESY NMR, and high resolution mass spectroscopy studies.

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