Modulation of aluminum sensing properties of a sulphone group containing chemosensor and its biological applications.

A chemosensor with two binding pockets facilitates binding of one metal ion in either of the pockets providing a better chance for the interaction and hence recognition of the cation. We report here a chemosensor, namely 2,2'-(1E)-(5,5'-sulfonylbis(2-hydroxy-5,1-phenylene))bis(azan-1-yl-1-ylidene)bis(methan-1-yl-1-ylidene)dinaphthalen-1-ol (HL-naph), for selective sensing of Al in DMF- HEPES buffer (1:4, v/v, pH 7.4).