Fractional optimal control strategies for hepatitis B virus infection with cost-effectiveness analysis.

Hepatitis B disease is a communicable disease that is caused by the hepatitis B virus and has become a significant health problem in the world. It is a contagious disease that is transmittable from person to person either horizontally or vertically. This current study is aimed at sensitivity analysis and optimal control strategies for a fractional hepatitis B epidemic model with a saturated incidence rate in the sense of the Caputo order fractional derivative approach.

Optimal Combinations of Control Strategies and Cost-Effectiveness Analysis of Dynamics of Endemic Malaria Transmission Model.

In this study, we propose and analyze a determinastic nonlinear system of ordinary differential equation model for endemic malaria disease transmission and optimal combinations of control strategies with cost effective analysis. Basic properties of the model, existence of disease-free and endemic equilibrium points, and basic reproduction number of the model are derived and analyzed. From this analysis, we conclude that if the basic reproduction number is less than unity, then the disease-free equilibrium point is both locally and globally asymptotically stable.

Non-linear dose response of DNA double strand breaks in response to chronic low dose radiation in individuals from high level natural radiation areas of Kerala coast.

Background: The human population living in high level natural radiation areas (HLNRAs) of Kerala coast provide unique opportunities to study the biological effects of low dose and low dose rate ionizing radiation below 100 mGy. The level of radiation in this area varies from < 1.0 to 45 mGy/year.

Assessment of safety and adverse drug reactions of COVID vaccination in the South Indian population: An observational prospective cross-sectional study.

Background: COVID vaccination is now offering a way to transit out of this phase of the pandemic. Two vaccines were approved by the Central Drugs Standard Control Organization (CDSCO) in India: Covishield and Covaxin. However, the vaccines are known to have Adverse Drug Reactions (ADRs) like fever, body pains, headache, pain, and swelling at the injection site.

Evaluation of the influence of chronic low-dose radiation on DNA repair gene polymorphisms [, , ] in individuals from normal and high level natural radiation areas of Kerala Coast.

Single Nucleotide Polymorphisms (SNPs) at DNA repair genes are considered as potential biomarkers of radio-sensitivity. The coastal belt of Kerala in south west India has a patchy distribution of monazite in its beach sand that contains Th-232 and its decay products. Thus, radiation levels in this area vary from <1.

Radio-adaptive response in peripheral blood lymphocytes of individuals residing in high-level natural radiation areas of Kerala in the southwest coast of India.

The present study investigates whether the chronic low-dose radiation exposure induces an in vivo radio-adaptive response in individuals from high-level natural radiation areas (HLNRA) of the Kerala coast. Peripheral blood samples from 54 adult male individuals aged between 26 and 65 years were collected for the study with written informed consent. Each of the whole blood sample was divided into three, one was sham irradiated, second and third was exposed to challenging doses of 1.

Peripheral blood lymphocyte micronucleus frequencies in men from areas of Kerala, India, with high vs normal levels of natural background ionizing radiation.

We have measured the frequencies of micronuclei (MN) in adult male individuals living in areas of the Kerala coast, southwest India, with either high (HLNRA, >1.5mGy/year) or normal levels of natural ionizing radiation (NLNRA, ≤1.5mGy/year).

Lack of increased DNA double-strand breaks in peripheral blood mononuclear cells of individuals from high level natural radiation areas of Kerala coast in India.

The high level natural radiation area (HLNRA) of Kerala is a 55km long and 0.5km wide strip in south west coast of India. The level of background radiation in this area varies from <1.

Sex ratio at birth: scenario from normal- and high-level natural radiation areas of Kerala coast in south-west India.

Newborns were monitored for congenital malformations in four government hospitals located in high-level (ambient dose >1.5 mGy/year) and normal-level (≤ 1.5 mGy/year) natural radiation areas of Kerala, India, from August 1995 to December 2012.

Effect of inorganic salts on the clouding behavior of hydroxypropyl methyl cellulose in presence of amphiphilic drugs.

In this paper we report the effect of two cationic (imipramine hydrochloride (IMP) and promazine hydrochloride (PMZ)) and one anionic (sodium salt of ibuprofen (IBF)) drugs on the clouding behavior of a nonionic polymer hydroxypropyl methyl cellulose (HPMC). Though all the three drugs increase the cloud point (CP) of HPMC, the effect was found to be minimum in the case of IBF. Further, the effect of adding salts (NaF, NaCl, NaBr, NaNO(3), Na(2)SO(4), Na(3)PO(4), KCl, KBr, KNO(3)) in the presence of amphiphilic drugs (IMP and PMZ) on the CP of HPMC was seen.

Effects of chronic low level radiation in the population residing in the high level natural radiation area in Kerala, India: employing heritable DNA mutation studies.

To study the effect of chronic low level radiation, 4040 meiosis were screened at eight microsatellite and five minisatellite (2485 and 1555 meiosis respectively) marker loci in people residing in high and normal level natural radiation areas of Kerala. Variants in the repeat length of allele were considered as mutants. Mutation rates (expressed as the number of mutations observed in the total number of meiosis) were 6.

Cytogenetic studies on newborns from high and normal level natural radiation areas of Kerala in southwest coast of India.

Purpose: To study, characterize and compare chromosome aberrations and karyotype anomalies among newborns from high (> 1.5 mGy/y) and normal (≤ 1.5 mGy/y) level natural radiation areas of monazite-sand bearing southwest coast of Kerala in India.

Inhalation and external doses in coastal villages of high background radiation area in Kollam, India.

The observational evidence for radiation-induced health effects in humans comes largely from the exposures to high doses received over short periods of time. The rate of induction of any health risk at low doses and dose rates is estimated by extrapolation from observations at high doses. Effects of low dose/low dose rate could be done by the study of populations that have been exposed to slightly above-average natural radiation doses.

Deposition-based passive monitors for assigning radon, thoron inhalation doses for epidemiological studies.

The International Commission on Radiological Protection dose limits for radiation protection have been based on linearly extrapolating the high-dose risk coefficients obtained from the Japanese A bomb survivor data to low doses. The validity of these extrapolations has been questioned from time to time. To overcome this, epidemiological studies have been undertaken across the world on populations chronically exposed to low-radiation levels.

Study of stillbirth and major congenital anomaly among newborns in the high-level natural radiation areas of Kerala, India.

Monitoring newborns for adverse outcomes like stillbirth and major congenital anomalies (MCA) is being carried out in government hospitals since 1995 in and around high-level natural radiation areas, a narrow strip of land on the southwest coast of Kerala, India. Natural deposits of monazite sand containing thorium and its daughter products account for elevated levels of natural radiation. Among 141,540 newborns [140,558 deliveries: 139,589 singleton, 957 twins (6.

Effect of low and chronic radiation exposure: a case-control study of mental retardation and cleft lip/palate in the monazite-bearing coastal areas of southern Kerala.

A population-based 1:3 age-matched case-control study was conducted during 2006-2009 to assess the role of high-level natural radiation (>1 mSv/year) on congenital mental retardation and cleft lip/palate in the southwest coastal area of Kerala. Dosimetry was carried out in the house where parents resided during conception and the subsequent two trimesters of pregnancy of the study subject. Conditional logistic regression did not suggest any statistically significant association of either mental retardation (n = 445) or cleft lip/palate (n = 116) with high-level natural radiation.

Studies on the mixed micelles of alkyltrimethylammonium bromides and butanediyl-1,4-bis(alkyldimethylammonium bromide) dimeric surfactants in the presence and absence of ethylene glycol at different temperatures.

Mixed micellization of two cationic dimeric surfactants butanediyl-1,4-bis(alkyldimethylammonium bromide) [C(m)H(2m+1)N(+)(CH(3))(2)-(CH(2))(4)-N(+)(CH(3))(2)C(m)H(2m+1),2Br(-)] with their monomeric counterparts alkyltrimethylammonium bromides [C(m)H(2m+1)N(+)(CH(3))(3)Br(-)](m=14 and 16) has been studied at different temperatures (298.15-323.15K) in presence and absence of ethylene glycol (EG) using conductivity data.

Effects of solvent media and temperature on the self-aggregation of cationic dimeric surfactant 14-6-14, 2Br- studied by conductometric and fluorescence techniques.

To explore how the solvent characteristics influence the self-aggregation of the cationic dimeric surfactant hexamethylene-1,6-bis(tetradecyldimethylammonium bromide) (14-6-14, 2Br(-)) and to obtain various energetic parameters, conductometric experiments were performed on the binary mixtures of three organic solvents--viz., 2-methoxyethanol (ME)-, acetonitrile (AN)-, and formamide (FA)- water (WR) at different temperatures ranging from 298.15 to 323.

Conductometric studies of micellization of gemini surfactant pentamethylene-1,5-bis(tetradecyldimethylammonium bromide) in water and water-organic solvent mixed media.

The micellization of gemini surfactant pentamethylene-1,5-bis(tetradecyldimethylammonium bromide) (14-5-14) has been investigated in water and water-organic solvent mixed media (organic solvents used: 1,4-dioxane (DO), dimethylformamide (DMF), ethylene glycol (EG)). The conductivity in water and in mixed media (water+organic solvent) as a function of surfactant concentration was measured at different temperatures and the data were used to find critical micelle concentration (cmc) and degree of counterion dissociation (alpha) of the micelle. From the study, it is observed that the micellization tendency of the surfactant decreases in the presence of organic solvents and the increase in the cmc values is comparatively less below 20% (v/v) of organic solvents showing the predominance of water character in the bulk phase at lower compositions of the organic solvents.

Influence of recall period on estimates of diarrhoea morbidity in infants in rural Tamilnadu.

Data collected on 689 infants, in a study to assess the incidence of diarrhoea and acute respiratory infections during infancy, is used here to quantify the extent of under-reporting in diarrhoea morbidity surveys. The study area consisted of two contiguous primary health centres in Villupuram health unit district in Tamil Nadu, South India. Each day of infancy was assigned a recal period and proportion of diarrhoeal days for various recall period computed.

Genetic monitoring of the human population from high-level natural radiation areas of Kerala on the southwest coast of India. II. Incidence of numerical and structural chromosomal aberrations in the lymphocytes of newborns.

Cytogenetic studies using cord blood samples from newborns from high-level natural radiation areas of the Kerala coast in Southwest India have been in progress since 1986. A total of 963,940 metaphases from 10,230 newborns have been screened for various types of chromosomal aberrations. Comparison of 8,493 newborns (804,212 cells) from high-level natural radiation areas (dose rate >1.

Genetic monitoring of the human population from high-level natural radiation areas of Kerala on the southwest coast of India. I. Prevalence of congenital malformations in newborns.

In the densely populated monazite-bearing sands of Kerala, on the southwest coast of India, natural radiation dose rates range from 1. 0 to over 35.0 mGy per year in certain well-defined high-level natural radiation areas.

Influence of recall period on estimates of diarrhoea morbidity in infants in rural Tamil Nadu.

Data collected on 689 infants, in a study to assess the incidence of diarrhoea during infancy, is used here to quantify the extent of under-reporting in diarrhoea morbidity surveys. The study area consisted of two contiguous primary health centres in Villupuram health unit district in Tamil Nadu, south India. Each day of infancy was assigned a recall period and proportion of diarrhoeal days for various recall period computed.

Effect of vitamin A supplementation to mother and infant on morbidity in infancy.

Objectives: To assess the impact of Vitamin A supplementation to the mother soon after delivery and to the infant at six months on morbidity in infancy.

Design: Randomized double blind placebo controlled field trial.

Setting: 51 villages in two contiguous Primary Health Centers in Villupuram Health Unit District of Tamil Nadu, South India.