Publications by authors named "Koya Osada"
Background: Arthroscopic partial meniscectomy (APM) is performed for symptomatic meniscal tears that fail conservative treatment. Patients often report pain at night, although little research has been done to evaluate corresponding outcomes.
Purpose: To (1) evaluate patients with and without preoperative nighttime pain who underwent APM and (2) assess postoperative resolution of symptoms and associated patient-reported outcome measures (PROMs).
Background: Treatment for osteochondritis dissecans (OCD) of the humeral capitellum has been predominantly guided by fragment stability and articular cartilage integrity. Nonoperative management is recommended for stable lesions, whereas surgical intervention is indicated for unstable lesions and those that fail nonoperative care. Several surgical options may be considered, although limited information is available regarding indications for specific surgical techniques and comparative postoperative results.
View Article and Find Full Text PDFArticle Synopsis
- Early life stress (ELS) in mice leads to cognitive issues and changes in dopamine receptor expression in the male offspring's anterior cingulate cortex (ACC).
- Fragmented maternal care during a critical neonatal period resulted in elevated D2R and suppressed D4R, impairing performance on visual attention tasks, but this could be reversed in adulthood through pharmacological interventions.
- ELS male mice also exhibited increased hypothalamic orexin and disrupted sleep patterns, pointing to sleep loss as a possible underlying factor for cognitive deficits, a correlation that extends to attention issues observed in children who experienced early adversity.
Single versus double percutaneous pinning of pediatric distal radius fractures.
J Pediatr Orthop B
March 2025
The aim of this study was to compare early clinical and radiographic results of single- versus double-pin fixation of unstable pediatric distal radius fractures. A total of 103 consecutive closed distal radius fractures treated with either single or double percutaneous pinning at a tertiary level I pediatric hospital were analyzed. All patients had open physes and had fractures that failed initial closed reduction and casting.
View Article and Find Full Text PDFBispecific T cell-engaging (BiTE) antibodies recruit polyclonal cytotoxic T cells (CTL) to tumors. One such antibody is carcinoembryonic antigen (CEA) BiTE that mediates T cell/tumor interaction by simultaneously binding CD3 expressed by T cells and CEA expressed by tumor cells. A widely operative mechanism for mitigating cytotoxic T cell-mediated killing is the interaction of tumor-expressed PD-L1 with T cell-expressed PD-1, which may be partly reversed by PD-1/PD-L1 blockade.
View Article and Find Full Text PDF