Publications by authors named "Kowit Pruegsanusak"
Objective: Routine screening for esophageal cancer in head and neck cancer patients in Thailand is controversial, because of concerns regarding the screening methods and cost effectiveness. Since Lugol dye chromoendoscopy is an effective technique for early detection of squamous cell carcinoma of the esophagus, the objectives of the present study are to evaluate the synchronous esophageal cancer in head and neck cancer patients and the effectiveness of Lugol dye chromoendoscopy for routine screening.
Material And Method: All diagnosed patients with head and neck cancer between September 1, 2009 and June 30, 2011 were enrolled into the study.
Objective: The study was aimed at analysing and identifying the proteins that are differentially expressed in oral squamous cell carcinoma (OSCC) compared to adjacent non-tumour tissue.
Materials And Methods: Two-dimensional (2D) sodium dodecyl sulphate-polyacrylamide gel electrophoresis accompanied by mass spectrometry (matrix-assisted laser desorption/ionisation-time-of-flight mass spectrometry and liquid chromatography-tandem mass spectrometry) was used to analyse and identify the differentially expressed proteins in 10 pairs of tumours and adjacent non-tumour tissues from five cases of early-stage and five cases of late-stage OSCC. The statistical differences of the protein spots were analysed by the Wilcoxon signed-rank test.
Objective: Determine the prognostic value of p53, Bcl-2 and Bax expression in cancer of the larynx.
Material And Method: Ninety-four patients diagnosed with laryngeal squamous cell carcinoma were analyzed for 5-year overall survival in relation to immunohistochemical expression of p53, Bcl-2, and Bax proteins.
Results: The present study included 86 males and eight females with a mean age of 65.
Article Synopsis
- Head and neck cancers are highly prevalent in southern Thailand, particularly with a high proportion (66.6%) of patients presenting at advanced stages (III and IV).
- In a study analyzing 1,186 patients treated between 2002-2004, five-year overall survival rates varied by cancer type, with the highest (38.0%) in laryngeal cancer and the lowest (19.2%) in hypopharyngeal cancer.
- Key prognostic factors include cancer stage and treatment type, with patients aged 80 and above facing poorer outcomes, highlighting the need for early detection and optimized treatment strategies.
Background: This study aimed to evaluate acute major toxicities, the response rate, 3-year overall survival and progression-free survival rate of locally advanced nasopharyngeal carcinoma patients on concurrent carboplatin chemoradiotherapy followed by carboplatin and 5-fluorouracil.
Methods: A prospective study of fifty patients diagnosed with locally advanced nasopharyngeal carcinoma received conventional radiation therapy with a total dose of 6600-7000 cGy in 6-7 weeks and concurrent chemotherapy of three cycles of carboplatin during radiotherapy, followed by adjuvant chemotherapy using carboplatin plus 5-fluorouracil for two cycles.
Results: Weight loss and mucositis were the two most common acute major grades 3-4 toxicities (42%).
Background: Tonsillectomy is a common procedure in children. It could produce moderate to severe post operative pain and morbidity. Preserving tonsillar capsule attached to pharyngeal constrictor muscle by microdebrider technique may reduce pain when compared to conventional cold dissection technique.
View Article and Find Full Text PDF