Navigating artificial general intelligence development: societal, technological, ethical, and brain-inspired pathways.

This study examines the imperative to align artificial general intelligence (AGI) development with societal, technological, ethical, and brain-inspired pathways to ensure its responsible integration into human systems. Using the PRISMA framework and BERTopic modeling, it identifies five key pathways shaping AGI's trajectory: (1) societal integration, addressing AGI's broader societal impacts, public adoption, and policy considerations; (2) technological advancement, exploring real-world applications, implementation challenges, and scalability; (3) explainability, enhancing transparency, trust, and interpretability in AGI decision-making; (4) cognitive and ethical considerations, linking AGI's evolving architectures to ethical frameworks, accountability, and societal consequences; and (5) brain-inspired systems, leveraging human neural models to improve AGI's learning efficiency, adaptability, and reasoning capabilities. This study makes a unique contribution by systematically uncovering underexplored AGI themes, proposing a conceptual framework that connects AI advancements to practical applications, and addressing the multifaceted technical, ethical, and societal challenges of AGI development.

Comparison of the Performance Parameters of BioHPP and Biocetal Used in the Production of Prosthetic Restorations in Dentistry-Part I: Mechanical Tests: An In Vitro Study.

The aim of these in vitro studies was to determine and compare the mechanical and tribological performance of two commercially available thermoplastic materials, namely BioHPP and Biocetal, used in dental prosthetics. In order to perform the comparative tests of both materials, the dog-bone shaped samples were formed by an injection molding process as in standard polymer materials research, wherein Biocetal samples constituted the research group, and BioHPP samples served as a control group. In the presented studies, their mechanical parameters were reported and analyzed: namely, Shore's hardness, unnotched impact strength, tensile strength, flexural strength, as well as abrasive wear resistance, obtained within appropriate tribological and mechanical tests.

Comparison of the Performance Parameters of BioHPP and Biocetal Used in the Production of Prosthetic Restorations in Dentistry-Part II: Physicochemical and Microbiological Tests: An In Vitro Study.

The natural aging process of the human organism leads to both physiological and pathological changes, including tooth loss. This requires dental prosthetic interventions aimed at restoring patients' quality of life. The use of such prostheses necessitates selection of sufficiently strong, aesthetic and biocompatible materials, which also offer ease of shaping.

The Influence of Sperm Activation Methods and Oocyte Collection on the Reproductive Effects of Northern Pike ().

This study compared the quality of northern pike eggs collected using traditional methods (hand stripping) and pneumatic methods (air stripping). The effects of different activation solutions (0.4% NaCl, 0.

Bioactive Compounds, Antioxidant Properties, and Antimicrobial Profiling of a Range of West Algerian Honeys: In Vitro Comparative Screening Prior to Therapeutic Purpose.

Honey is a complex natural nutrient with well-established therapeutic properties recognized in traditional medicine. The purpose of the current work was to compare, in vitro, the bioactive compounds, antioxidants, and antimicrobial properties of 37 honey samples collected from the western region of Algeria and to identify the best sample for potential therapeutic purposes. Estimation of bioactive compounds was carried out by determining the total phenolic and flavonoid contents.

Search for Fractionally Charged Particles with CUORE.

The Cryogenic Underground Observatory for Rare Events (CUORE) is a detector array comprised by 988 5  cm×5  cm×5  cm TeO_{2} crystals held below 20 mK, primarily searching for neutrinoless double-beta decay in ^{130}Te. Unprecedented in size among cryogenic calorimetric experiments, CUORE provides a promising setting for the study of exotic throughgoing particles. Using the first tonne year of CUORE's exposure, we perform a search for hypothesized fractionally charged particles (FCPs), which are well-motivated by various standard model extensions and would have suppressed interactions with matter.

Mattering Matters: Examining the Moderating Role of Mattering in Cyberbullying Victimization-Outcome Relationships Among College Students.

Recognized as a public health threat, cyberbullying victimization (CV), or bullying experienced through digital technologies, is mostly studied among adolescents, but evidence among college students suggests that it is prevalent and linked with negative outcomes. One protective factor that might reduce the impact of CV is mattering, which involves feeling significant and valued by others. In this study, we explored five hypotheses, including examining the moderating role of mattering in four CV-outcome relationships (self-esteem, life satisfaction, depression, and academic performance).

Biological characterization of AB-343, a novel and potent SARS-CoV-2 M inhibitor with pan-coronavirus activity.

Since the SARS-CoV-2 outbreak, there have been ongoing efforts to identify antiviral molecules with broad coronavirus activity to combat COVID-19. SARS-CoV-2's main protease (M) is responsible for processing the viral polypeptide into non-structural proteins essential for replication. Here, we present the biological characterization of AB-343, a covalent small-molecule inhibitor of SARS-CoV-2 M with potent activity in both cell-based (EC = 0.

Structure-Activity Relationships and Discovery of ()-5-(-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2',1':2,3]imidazo[4,5-]quinoline-3-carboxylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer.

Lowering hepatitis B surface antigen (HBsAg) levels from covalently closed circular DNA (cccDNA) and the integrated genome could reduce the persistence of hepatitis B virus (HBV) infection. Since HBV replication occurs in the liver and to ameliorate the peripheral neuropathy observed with a first-generation tricyclic 4-pyridone PAPD5/7 inhibitor () having high systemic exposure, we focused on increasing the hepatocyte concentration and reducing plasma levels. Optimization of a novel series of PAPD5/7 inhibitors that decrease HBsAg levels led to the tetracyclic 2-pyridone , which was similarly potent to and but showed dramatically higher rodent liver-to-plasma ratios.

Unidirectional ray polaritons in twisted asymmetric stacks.

The vast repository of van der Waals (vdW) materials supporting polaritons offers numerous possibilities to tailor electromagnetic waves at the nanoscale. The development of twistoptics-the modulation of the optical properties by twisting stacks of vdW materials-enables directional propagation of phonon polaritons (PhPs) along a single spatial direction, known as canalization. Here we demonstrate a complementary type of directional propagation of polaritons by reporting the visualization of unidirectional ray polaritons (URPs).

Stability and Dynamics of Zeolite-Confined Gold Nanoclusters.

Nanoengineered metal@zeolite materials have recently emerged as a promising class of catalysts for several industrially relevant reactions. These materials, which consist of small transition metal nanoclusters confined within three-dimensional zeolite pores, are interesting because they show higher stability and better sintering resistance under reaction conditions. While several such hybrid catalysts have been reported experimentally, key questions such as the impact of the zeolite frameworks on the properties of the metal clusters are not well understood.

Electroreduction of Captured CO on Silver Catalysts: Influence of the Capture Agent and Proton Source.

In the context of carbon reutilization, the direct electroreduction of captured CO (c-CORR) appears as an appealing approach since it avoids the energetically costly separation of CO from the capture agent. In this process, CO is directly reduced from its captured form. Here, we investigate the influence of the capture agent and proton source on that reaction from a combination of theory and experiment.

Expanding the Sexual Experiences Survey to Include Technology Facilitated Sexual Exploitation.

The Sexual Experiences Survey is the most widely used measure of sexual assault victimization and perpetration among college students. To improve comprehensiveness and inclusiveness, the current revision of the victimization items of the SES (SES-V; Koss et al., 2024) included the addition of a module focusing on Technology Facilitated Sexual Exploitation (TFSE).

The Revised Sexual Experiences Survey Victimization Version (SES-V): Conceptualization, Modifications, Items and Scoring.

The Sexual Experiences Survey [SES] is considered the gold standard measure of non-consensual sexual experiences. This article introduces a new victimization version [SES-V] developed by a multidisciplinary collaboration, the first revision since 2007. The 2024 SES-V is designed to measure the construct of sexual exploitation since the 14th birthday.

Preliminary Evidence of Validity for the Verbally Pressured and Illegal Sexual Exploitation Modules of the Sexual Experiences Survey-Victimization.

The Sexual Experiences Survey-Victimization (SES-V; see Koss et al., 2024) revises the prior 2007 Sexual Experiences Survey-Short Form Victimization (SES-SFV) in many ways, including expanded measurement of verbally pressured and illegal sexual exploitation, as well as the addition of items that assess being made to perform a sexual act or to penetrate another person sexually. The current article describes two initial validity studies of the SES-V.

Optimization of Antifungal Properties of Hop Cone Carbon Dioxide Extracts Based on Response Surface Methodology.

Response surface methodology (RSM) was employed to optimize the process parameters of the supercritical carbon dioxide extraction of hop cones in terms of their antifungal properties against and . The effects of temperature (40-50 °C), pressure (200-300 bar), and CO consumption (25-75 kgCO/kg) on the extraction yield, content of α- and β-acids, as well as pathogens' growth inhibition were investigated. Both pressure and CO consumption had a significant effect on antifungal properties.

Antioxidant Activity of Phenolic Hop Extracts in Creating a New Pâté: An Element Affecting Fat Stability and Microbiological Quality during Storage.

The aim of this study was to evaluate the effect of hop extracts on changes in the primary and secondary fat oxidation products, physicochemical properties, and microbiological quality of pâté-type offal sausages obtained through the partial replacement of animal fat with vegetable fat. This study demonstrated that the extraction efficiency varied among hop cone varieties, with the highest efficiency observed for the Lubelski variety and the lowest for the Magnum variety. The phenolic compound content was higher in the Magnum cones (2.

Fake news research trends, linkages to generative artificial intelligence and sustainable development goals.

In the digital age, where information is a cornerstone for decision-making, social media's not-so-regulated environment has intensified the prevalence of fake news, with significant implications for both individuals and societies. This study employs a bibliometric analysis of a large corpus of 9678 publications spanning 2013-2022 to scrutinize the evolution of fake news research, identifying leading authors, institutions, and nations. Three thematic clusters emerge: Disinformation in social media, COVID-19-induced infodemics, and techno-scientific advancements in auto-detection.

Psychological dread and extreme persistent fear.

Psychological dread is a phenomenon with which virtually everyone is familiar, whether dreading a medical appointment, a job interview, or the impending death of a loved one. Despite the prevalence of dread in most people's everyday lives, surprisingly little empirical research has explored the construct. The purpose of the current research was to examine psychological dread (Study 1 and Study 2) and to compare dread to extreme persistent fear (Study 2).

The Effect of Peppermint and Thyme Oils on Stabilizing the Fatty Acid Profile of Sunflower Oil.

Presently, there is an increasing shift towards the utilization of natural antioxidants and compounds with protective attributes for fatty acids in order to replace synthetic counterparts that may pose health risks. This transition aligns with the growing emphasis on promoting healthy and organic food choices. Essential oils stand out in this context due to scientific validations of their antioxidant properties.

Correlation of wastewater surveillance data with traditional influenza surveillance measures in Cook County, Illinois, October 2022-April 2023.

Influenza is a respiratory illness that can result in serious outcomes, particularly among persons who are immunocompromised, aged <5 years or aged >65 years. Traditional influenza surveillance approaches rely upon syndromic surveillance of emergency departments and public health reporting from clinicians and laboratories. Wastewater surveillance infrastructure developed to monitor SARS-CoV-2 is being used for influenza surveillance in the Chicago area.

A rise in the frequency of mutant among keratitis isolates between 1993 and 2021.

Introduction: causes vision threatening keratitis. The transcription factor regulates virulence factors in response to the quorum sensing molecule N-3-oxo-dodecanoyl-L-homoserine lactone. isolates with mutations are characterized by an iridescent high sheen phenotype caused by a build-up of 2-heptyl-4-quinolone.

Case report: First treatment of acute ischaemic stroke in a patient on active rivaroxaban therapy using andexanet alfa and rtPA combined with early complete recovery.

Unlabelled: Patients with non-large vessel occlusion acute ischemic stroke (NL-AIS) on oral anticoagulants (OAC) constitute the biggest portion among those who cannot receive any potential-reperfusion treatment even if they appear early in the hospital. We present the first case of therapy for NL-AIS in a patient with active anti-Xa anticoagulation, combining andexanet alfa and rtPA, who was recruited for STRoke On AntiCoagulants for Thrombolysis (acronym: STROACT), an ongoing therapeutic trial for non-LVO ischemic stroke on a DOAC. This is also the first report of the use of andexanet alfa-rtPA for AIS in a patient on rivaroxaban, which is the most frequently used non-vitamin K antagonist oral anticoagulant.