[THERAPEUTIC ACTIVITY OF MICRONIZED MEBENDAZOLE IN THE MUSCULAR PHASE OF EXPERIMENTAL TRICHINELLA SPIRALIS INVASION IN ALBINO MICE].

The incidence of trichinosis in Russia was 0.07 per 100,000 population in 2014, which was 2.9-fold higher than that in 2013.

[EFFICACY OF A NEW MEBENDAZOLE FORMULATION FOR EXPERIMENTAL ECHINOCOCCUS GRANULOSUS LARVAL INVASION IN ALBINO MICE].

The problem of echinococcosis has acquired special urgency in Russia in the last 10 years. The dramatically worse epidemiological situation of echinococcosis in the country is suggested by just frequent cases of cystic echinococcosis in the indigenous population of Moscow and its region, including children. Currently, albendazole that is less toxic than mebendazole remains the drug of choice, However, some authors note that E.

[Comparative efficacy of original oil escazole and nemozole suspensions in albino mice with experimental trichinosis in the muscle phase of invasion].

The efficacy of original oil escazole and nemozole suspensions in albino mice in the muscle phase of T. spiralis invasion, which was detected by lifetime diagnosis of experimental trichinosis 6 days after initiation of treatment in a daily dose of 0.3 g/kg, was 100%.

[Efficacy of nocodazole et experimental invasion Echinococcus granulosus of white mice].

The therapeutic activity of subcutaneous and intraperitoneal nocodazole injections was studied in albino mice with experimental E. granulosus invasion. The animals were intraperitoneally infected with Echinococcus larval cysts (ELC) from a spontaneously inoculated sheep.

[Study of the therapeutic activity of nocodazole on experimental models of larval alveococcosis].

The therapeutic activity of parenteral nocodazole was studied on four larval alveococcosis models: golden hamsters (Mesocricetus auratus), Djungarian hamsters (Phodopus sungorus campbelli Thomas), albino rats (Rattus rattus albus), and cotton rats (Sigmodon hispidus) at the late stage of E. multilocularis invasion. The agent (aqueous suspension) was intraperitoneally, intramuscularly, and subcutaneously injected in daily doses of 0.

[Comparative efficacy of albendazole and mebendazole oily suspensions in albino mice with experimental larval alveococcosis].

The comparative efficacy of albendazole and mebendazole oily suspensions (AOS and MOS) was studied in an experimental model of experimental larval alveococcosis in albino mice. The animals were intragastrically injected with the agents once daily for 40 days on day 35 after intraperitoneal inoculation with E. multilocularis acephalocysts.

[Lifetime diagnosis of trichinosis in experimentally infected laboratory animals].

The authors propose a new method for lifetime diagnosis (LTD) of experimental invasion of Trichinella spiralis in migratory and muscular phases, which is based on thin-layer microscopy of minor samples of skeletal muscles (weighing 1-1.5 mg) on gradually increased impulse manual compression. The LTD method permits the monitoring of the most important follow-up qualitative and quantitative invasion parameters in each infected animal in normalcy and under the action of specific therapeutic and preventive agents (the onset and termination of a migratory phrase, the elimination time of intestinal Trichinella after infection, the number, sizes, morphological features, viability, and motor activity of nonincapsulated and incapsulated muscular Trichinella larvae of different age).

[Experimental model of activated Lamblia (Giardia) muris infection in albino mice].

Experimental L. muris infection was reproduced in 100% of the intact albino mice intragastrically given levomycin in an average total dose of 15.88-34.

[The specific features of development of Echinococcus granulosus metacestode (exogenous blastogenesis) in man].

The paper describes a case of abnormal development of a parasitic cyst by the type characteristic of alveolar echinococcosis (exogenous blastogenesis) detected in a female patient operated on for echinococcus. The fact that the exogenous blastogenesis has been found allows the mechanism of a postoperative recurrence of human echinococcosis to be explained from basically new standpoints. A parasitological analysis of the punctates of cystic masses and cysts themselves, taken from patients operated on for cystic echinococcosis has revealed one of the signs of malignant exogenous proliferation of elements of a parasytic metacestode, namely, the development of acephalocysts from the germinative cells of the pedicle of protoscoleces.

[Experimental grounds of a new concept of Opisthorchis felineus infection formation in a definitive host].

In the course of experiments in was found out that golden hamsters having the bilious duct operationally blocked display receptivity to the infection with the non-excysted Opisthorchis felineus metacercariae passed to the stomach. Excysted metacercariae injected to the system of the portal vein settle down in the bilious pathways of the liver and develop there up to the adult stage. In vitro, the metacercariae survive in the blood serum of the intact golden hamsters during one day.

[Activity of the anthelmintic agent trichlorophen on the models of human helminthiasis].

Trials of trichlorophen have shown its high efficacy on models of cestode infections: hymenolepiasis (at the adult and cysticercoid stages of development on three types of animals: outbred albino mice, albino rats and golden hamsters), preimaginal echinococciasis alveolaris, larval alveolar echinococciasis (at the early stage of development of the parasite in experiments on cotton rats). The high nematodical activity of trichlorophen was first found on models of trichocephaliasis in DBA/2y mice, nippostrongyloidiasis (in in vitro experiments), and aspiculuriasis in outbred mice. The agent proved to be ineffective at the tissue developmental stage of Hymenolepsis nana (H.

[Experimental rationale for the use of medapec as the drug of choice in treating echinococcosis].

The dosage form of medamine-medapec was found to have a high antiechinococcal activity in experiments on laboratory animals. Its efficacy was shown in treating larval alveolar echinococciasis in mice and cotton rats with different doses and courses as compared with medamine and albendazole. It was ascertained that for its high larvicidal activity, medapec should be given to animals regularly during a day.

[Developing of new anthelmintics. Evaluation of fluzamide on the new experimental models of intestinal cestode infections].

The efficacy of the original drug fluzamide (a N,S-containing heterocycle derivative) was evaluated by primary screening on a modified model of monoinvasion with the luminal form of Echinococcus multilocularis and on an original model of intestinal mixed invasion of E. multilocularis and Hymenolepsis nana at the immature and mature stages of the parasites in golden hamsters when an experimental host was immunosuppressed with hydrocortisone. The efficacy of fluzamide in an oral dose of 0.

[Homeopathic preparation Cheblin-CK-1 in the pathogenetic therapy of echinococcosis].

This study was experimental and clinical. The experiments were made on 80 cotton rats. The clinical study covered 289 patients operated on for echinococcosis.

[An improvement in a new method for the surgical treatment of echinococcosis].

Parasitic cysts were intraoperatively treated with glycerol in 179 patients with echinococcosis at various sites and 3% hydrogen peroxide in 165 patients with hepatic echinococcosis. Experiments on 60 cotton rats experimentally infected with Echinococcus alveolaris and 156 albino mice with E. granulosus provided evidence for the surgical use of 80-100% glycerol or 3% hydrogen peroxide to treat the cysts.

[Treatment of hydatid cysts' residual cavities (experimental and clinical study)].

Experimental series of 60 cotton rats and 150 white mice infected with echinococcus showed that 80-100% glycerin and 3% peroxide solution were effective scolicidal solutions for inactivation of the parasite. 344 patients have been operated on for hydatid disease with inactivation of the parasite by means of these scolicidal solutions. Glycerin during the surgical management of the hydatid cysts is effective and harmless in uncomplicated hydatid liver disease and any hydatid pulmonary cysts.

[Experimental echinococcosis and alveococcosis and a trial of the preparation SK-1].

In autobred albino mice, the maximum nonlethal dose of the agent CK-1 was established, which was 19.0 g/kg, the agent was nontoxic. Cotton rats aged 30-45 days were infected by alveococcosis from a donor rat.

[The search for new antiparasitic agents. 17. The synthesis and study of the anti-echinococcal activity of the new preparation G-1697].

The paper describes the synthesis of the new agent G-1697 which is 4-[(benzo-2,1,3-thiadiazolyl-4)amino]-5, 6,7,8-tetrahydrobenzothieno [2,3-d] pyrimidine and the results of testing its acute toxicity and antiparasitic activity on a model of Echinococcus multilocularis invasion at the larval stage in cotton rats. The maximum nonlethal dose of G-1697 was 4.0 g/kg for outbred mice of both sexes whose weight was 14-16 g.

[The host-opportunistic protozoa system. The outcome of a Leishmania infantum infection in white rat pups naturally resistant to Leishmania infection].

It was found out, that non-lineal young white rats have a natural resistance to the leishmania infection, but it could be overcome with the mean of immunosuppression caused by the corticosteroid of prolonged action Tricort-40. The leishmania infection caused by immunosuppression is successfully eliminated by the animal organism soon after the stopping of immunosuppressant action, that could be considered as the restitution of the natural resistance.

[The host-opportunistic protozoon system. The manifestation of Leishmania infantum infection in naturally resistant adult white rats subjected to drug immunosuppression].

The attempt to overcome the natural resistance of white rats Wistar to Leishmania infantum infection was made by the mean of the immunodepressant Tricort-40, the corticosteroid of prolonged activity. In the series of experiments with the mercy scheme of immunosuppression the inoculation of the amastigotes L. infantum taken out of the donors, the golden hamsters Mesocricetus auratus, caused the progressive infection with intensive affection on target organs (the spleen, liver, bone marrow).

[The host-opportunistic protozoa system. The dissemination of Leishmania infantum infection in naturally susceptible laboratory animals subjected to drug-induced immunosuppression].

The possibility to awake the disseminated infection of Leishmania infantum in golden hamsters Mesocricetus auratus, hispid cotton rats Sigmodon hispidus, soft furred rats Mastomys natalensis by means of different immunodepressants has been examined. On the background of the immunosuppression caused by corticosteroids of short time activity (metipred, hydrocortison) leishmaniae were revealed both in the target organs (spleen, liver, marrow) and in lungs, in cases of using the corticosteroid of prolonged activity (tricort-40) leishmaniae were observed also in lungs, kidneys, testis.

[The search for new antiparasitic agents. 12. The synthesis and study of the anti-Echinococcus and anti-Hymenolepis activity of 6-[4-(4-alkylpiperazinyl-1)-phenylamino]-1,2,5-thiadazolo[3 ,4-h] quinolines].

The paper describes the synthesis of 6-[4-alkylpiperazinyl-1)phenylamino]-1,2,5-thiadiazolo[3,4-h ]quinolines where methyl (Drug G-1574) and ethyl (Drug G-1569) are alkyls. The two agents are as effective as mebendazole against the larval stage of Echinococcus multilocularis infection. Drug G-1574 has been demonstrated to ensure 100% recovery of spontaneously Hymenolepis nana-infected albino mice given doses 2.

[The host-opportunistic protozoa system. The dissemination of Pneumocystis infection in white rats under the influence of drug-induced and biological immunosuppression].

The main purpose of the present study is the investigation of relationships of Pneumocystis carinii with the organism of white rat Wistar, which is natural carrier of this parasite. The series of experiments has shown that the immunosuppressor Tricort-40 (corticosteroid of prolonged activity) in a short time reactivates the Pneumocystis infection. The parasites have been observed in a great number in the lungs and rarely in the liver.