[Experimental hybridization of voies of the genus Microtus s.l. M. socialis with species of the group arvalis (Mammalia, Rodentia)].

The results of interspecific crosses of the social vole Microtus socialis with the Altai vole M. obscurus, the East European vole M. rossiaemeridionalis, and the Transcaspian vole M.

[Cytogenetic study of the parapatric contact zone between two 46-chromosomal forms of the common vole in European Russia].

Since the first description of sympatric sibling species and allopatric chromosomal forms of the common vole (Microtus arvalis group) in 1969, the search of their range boundaries has been Continually going on up to the present time. Based on the cytogenetic material presented in the present study, the geographical distribution of two karyoforms (2n = 46: NF = 84 and NF = 72) was examined in 20 geographic localities of European Russia (within the interval between the longitude 34 degrees-56 degrees East and 51 degrees-61 degrees). The places of findings of two karyoforms, "arvalis" and "obscurus", in Russia have been supplemented and were shown to be significantly closer; whereas the well-known distribution boundaries for the "obscurus" form were specified in the northern and southern parts of Russia.

[The influence of clexane on the fibronectin content in the blood plasma in patients with destructive pancreatitis].

The fibronectin content dynamics in the blood serum was estimated in patients with various clinical forms of an acute pancreatitis. The fibronectin level lowering may be a predictor of occurrence and diagnostical criterion for infective complications in patients with destructive pancreatitis. Application of clexane had promoted the fibronectin level raising in the blood serum in patients with sterile and infected pancreatic necrosis.

[Choice of surgical strategies in the treatment of multiple postnecrotic pancreatic pseudocysts].

The results of treatment of patients with multiple pancreatic pseudocysts are presented. The surgical tactics choice, depending on size, localization of pseudocysts, the state of their wall and connection with pancreatic duct, was substantiated.

[The effect of certain factors on the prognosis of the course of acute pancreatitis].

An analysis of treatment of 2740 patients with acute destructive pancreatitis from 1973 up to the present has been performed together with that of relevant published literature. Different factors of diagnosis and those of treatment of acute pancreatitis were found to influence the prognosis of the illness in some way or other. It has been noted that delayed surgery permit obtaining better results.

[The basic stages in the diagnosis and treatment of necrotic forms of acute pancreatitis].

An analysis has been performed of results of treatment of 2740 patients with acute destructive pancreatitis over the period between 1973 and the present time, together with those from published literature. Based on the above analysis, an algorithm has been developed to be used in diagnosis and treatment of necrotic forms of pancreatitis, that permitted reducing the postoperative mortality associated with the pathology under consideration from 31.3% to 14.

[The combined treatment of acute destructive pancreatitis].

Extensive resection of the pancreas is shown to be accompanied by a high case-fatality rate and unsatisfactory late results such as formation of postpancreatectomy syndrome. Expediency is proved of employment of conservative treatment (pancreatic secretion blockers, antioxidants, antibiotics, different kinds of extracorporal and intracorporal detoxication etc.).

[Current approaches to the treatment of acute destructive pancreatitis].

The experience of treatment of 2740 patients with an acute pancreatitis (AP) in 1973-1998 years was summarized. The efficacy of an active-surgical, active-temporizing and conservative tactics was estimated, the basic components of conservative therapy, indications to surgical treatment of an AP were considered.

[Genetic differentiation of voles of the tribe Arvicolini (Cricetidae, Rodentia) using taxonprint analysis and polymerase chain reaction with random primers].

The variability of the genomes of ten vole species was analyzed by means of taxonomic DNA fingerprinting and polymerase chain reaction using random primers (RAPD-PCR). The dendrograms of genetic similarity between the representatives of the tribe Arvicolinae (Gray, 1821) were constructed, based on the data obtained by means of both methods. The topology of the genetic similarity dendrogram that is based on the RAPD-PCR data generally correlates with the genetic distances estimated from biochemical and karyological data.

[Subcutaneous pancreatic islets transplantation of newborn piglets as a method for a surgical correction in the course of diabetic angiopathy].

The xenotransplantation conduction results of pancreatic insular cells of newborn piglets to 61 patients with diabetes mellitus. Positive changes of the diabetic angiopathy clinical course were noted in 91.1% of patients.