Hallucinations in Hearing Impairment: How Informed Are Clinicians?

Background And Hypothesis: Patients with hearing impairment (HI) may experience hearing sounds without external sources, ranging from random meaningless noises (tinnitus) to music and other auditory hallucinations (AHs) with meaningful qualities. To ensure appropriate assessment and management, clinicians need to be aware of these phenomena. However, sensory impairment studies have shown that such clinical awareness is low.

Directionality quantification of in vitro grown dorsal root ganglion neurites using Fast Fourier Transform.

Background: The directionality analysis of the neurite outgrowths is an important methodology in neuroscience, especially in determining the behavior of neurons grown on silicon substrates.

New Method: Here we aimed to describe the methodology for quantification of the directionality of neurites based on the Fast Fourier Transform (FFT). We performed an image analysis case study that incorporates several software solutions and provides a rapid and precise technique to determine the directionality of neurites.

Stimulation Rate and Voice Pitch Perception in Cochlear Implants.

The stimulation rate in cochlear implant (CI) sound coding, or the "carrier" rate in pulses per second (pps), is known to influence pitch perception, as well as loudness perception and sound quality. Our main objective was to investigate the effects of reduced carrier rate on the loudness and pitch of coded speech samples. We describe two experiments with 16 Nucleus® CI users, where we controlled modulation characteristics and carrier rate using Spectral and Temporal Enhanced Processing (STEP), a novel experimental multichannel sound coder.

Implantable, Programmable, and Wireless Device for Electrical Stimulation of the Dorsal Root Ganglion in Freely-Moving Rats: A Proof of Concept Study.

Objective: This was a proof of concept study, based on systematic reviews of the efficacy and safety of the dorsal root ganglion (DRG) stimulation. The main objective was to develop an implantable, programmable, and wireless device for electrical stimulation of DRG and a methodology that can be used in translational research, especially to understand the mechanism of neuromodulation and to test new treatment modalities in animal models of pain.

Methods: We developed and tested a stimulator that uses a battery-powered microelectronic circuit, to generate constant current square biphasic or monophasic pulsed waveform of variable amplitudes and duration.

Supporting Equity and Inclusion of Deaf and Hard-of-Hearing Individuals in Professional Organizations.

Disability is an important and often overlooked component of diversity. Individuals with disabilities bring a rare perspective to science, technology, engineering, mathematics, and medicine (STEMM) because of their unique experiences approaching complex issues related to health and disability, navigating the healthcare system, creatively solving problems unfamiliar to many individuals without disabilities, managing time and resources that are limited by physical or mental constraints, and advocating for themselves and others in the disabled community. Yet, individuals with disabilities are underrepresented in STEMM.

The influence of consumer ethnocentrism on purchase of domestic wine: Application of the extended theory of planned behaviour.

With the globalization of markets, consumers are increasingly confronted with a wide range of domestic and foreign products. One of the elements influencing purchase choice of domestic over foreign products are consumer ethnocentric tendencies. There are few studies that have focused on the impact of consumer ethnocentrism on domestic products purchase in developing nations.

Guided growth with aligned neurites in adult spiral ganglion neurons cultured in vitro on silicon micro-pillar substrates.

Objective: Assessment of the relationship between the topographical organization of silicon micro-pillar surfaces (MPS) on guidance and neural alignment of adult spiral ganglion neurons (SGN) and use of the otosurgical approach as an alternative for the extraction and isolation of SGNs from adult guinea pigs.

Approach: SGNs from adult guinea pigs were isolated using conventional and otosurgical approach for in vitro cell culturing on MPS of various micro-pillar widths (1-5.6 µm) and spacing (0.

Advantageous environment of micro-patterned, high-density complementary metal-oxide-semiconductor electrode array for spiral ganglion neurons cultured in vitro.

This study investigated micro-patterned, high-density complementary metal-oxide-semiconductor (CMOS) electrode array to be used as biologically permissive environment for organization, guidance and electrical stimulation of spiral ganglion neurons (SGN). SGNs extracted and isolated from cochleae of P5-P7 rat pups and adult guinea pigs were cultured 1, 4 and 7 days in vitro on glass coverslips (control) and CMOS electrode array. The cultures were analyzed visually and immunohistochemically for SGN presence, outgrowth, neurite alignment, neurite length, neurite asymmetry as well as the contact of a neuronal soma and neurites with the micro-electrodes.

Microelectrode array-induced neuronal alignment directs neurite outgrowth: analysis using a fast Fourier transform (FFT).

Many studies have shown that the topography of the substrate on which neurons are cultured can promote neuronal adhesion and guide neurite outgrowth in the same direction as the underlying topography. To investigate this effect, isotropic substrate-complementary metal-oxide-semiconductor (CMOS) chips were used as one example of microelectrode arrays (MEAs) for directing neurite growth of spiral ganglion neurons. Neurons were isolated from 5 to 7-day-old rat pups, cultured 1 day in vitro (DIV) and 4 DIV, and then fixed with 4% paraformaldehyde.

Auditory nerve frequency tuning measured with forward-masked compound action potentials.

Frequency selectivity is a fundamental cochlear property. Recent studies using otoacoustic emissions and psychophysical forward masking suggest that frequency selectivity is sharper in human than in common laboratory species. This has been disputed based on reports using compound action potentials (CAPs), which reflect activity in the auditory nerve and can be measured in humans.

Ongoing temporal coding of a stochastic stimulus as a function of intensity: time-intensity trading.

Stimulus-locked temporal codes are increasingly seen as relevant to perception. The timing of action potentials typically varies with stimulus intensity, and the invariance of temporal representations with intensity is therefore an issue. We examine the timing of action potentials in cat auditory nerve to broadband noise presented at different intensities, using an analysis inspired by coincidence detection and by the binaural "latency hypothesis.

Integrity of gut mucosa during anaesthesia in major abdominal surgery.

The aim of the study was to examine a perfusion and integrity of small bowel in 60 subsequent patients during the major open abdominal surgery which lasted from 2 to 7 hours. Two samples of the intestinal mucosa were removed: at the beginning, and at the end of the surgical procedure in general anaesthesia. A mucosal injury was classified into 4 grades.

Hearing history influences voice gender perceptual performance in cochlear implant users.

Objectives: The study was carried out to assess the role that five hearing history variables (chronological age, age at onset of deafness, age of first cochlear implant [CI] activation, duration of CI use, and duration of known deafness) play in the ability of CI users to identify speaker gender.

Design: Forty-one juvenile CI users participated in two voice gender identification tasks. In a fixed, single-interval task, subjects listened to a single speech item from one of 20 adult male or 20 adult female speakers and had to identify speaker gender.

Voice gender perception by cochlear implantees.

Gender identification of human voices was studied in a juvenile population of cochlear implant (CI) users exposed to naturalistic speech stimuli from 20 male and 20 female speakers using two different voice gender perception tasks. Stimulus output patterns were recorded from each individual CI for each stimulus, and features related to voice fundamental frequency and spectral envelope were extracted from these electrical output signals to evaluate the relationship between implant output and behavioral performance. In spite of the fact that temporal and place cues of similar quality were produced by all CI devices, only about half of the subjects were able to label male and female voices correctly.

Mutations that modulate receptor-hormone congruency as a cause of the primate GH receptor species specificity.

Peptide hormones depend on reliable recognition by their receptors. Any mutation that compromises recognition of hormone and receptor molecules is dangerous, the carrier animal would not procreate and the mutation would be lost. Although, most of the hormones from one mammalian species are active when injected into another, the incompatibility of human GH receptor toward nonprimate GHs is a notable exception.

The gender congruency effect and the selection of freestanding and bound morphemes: evidence from croatian.

The authors report 3 picture-word interference experiments in which they explore some properties of the agreement process in speech production. In Experiment 1, Croatian speakers were asked to produce utterances in which the noun's gender value had an impact on the selection of gender-marked freestanding morphemes (pronouns) while ignoring the presentation of same- or different-gender distractor words. In Experiments 2 and 3, Croatian speakers were asked to name the same pictures using noun phrases in which the noun's gender value surfaced as an inflectional suffix.

Sounds and silence: an optical topography study of language recognition at birth.

Does the neonate's brain have left hemisphere (LH) dominance for speech? Twelve full-term neonates participated in an optical topography study designed to assess whether the neonate brain responds specifically to linguistic stimuli. Participants were tested with normal infant-directed speech, with the same utterances played in reverse and without auditory stimulation. We used a 24-channel optical topography device to assess changes in the concentration of total hemoglobin in response to auditory stimulation in 12 areas of the right hemisphere and 12 areas of the LH.

[Catheter placement for peritoneal dialysis using videoendoscopy].

From December 1993 to December 2000 at the Department of Surgery, General Hospital "Sveti Duh", and University, Hospitals Split and Osijek the catheter for peritoneal dialysis was placed in 128 patients, in 137 cases. Videoendoscopic procedure, with the trocar made precisely for that purpose, was used. All surgical procedures, performed in the completely equipped operation room and in general anesthesia, were done without any intraoperative or postoperative complications.