Abnormal glucose metabolism in the anterior cingulate cortex in patients with schizophrenia.

Changes in glucose metabolism were studied in the brains of schizophrenic patients treated with neuroleptics, using [(18)F]fluoro-deoxy-glucose positron emission tomography (FDG-PET). Fourteen male and eight female patients in their thirties and forties were studied in a resting state. Data from FDG-PET were processed with an anatomic standardization method, three-dimensional stereotactic surface projections (3D-SSP), which provided relative glucose metabolic values that mitigated the contamination of brain atrophy.