Publications by authors named "Kouta Mashima"
Hypersensitivity reactions are an adverse effect of anticancer drug therapy. Prophylactic administration of antiallergic drugs and steroids is recommended when administering drugs associated with a high hypersensitivity reaction incidence. First-generation antihistamines are generally used in this setting.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of the CARG prediction tool for forecasting grade ≥3 chemotherapy-related adverse events (CRAE) in older Japanese cancer patients.
- The research involved 165 patients aged 65 and older, categorizing them into low, medium, and high-risk groups based on their CARG scores, showing a significant increase in CRAE incidence with higher risk scores.
- Results indicated that the CARG tool is promising for predicting non-hematological toxicities and severe hematological toxicities among this demographic, marking it the first study to validate such a prediction tool specifically for older Japanese patients.
Albumin-bound paclitaxel(nab-PTX)-associated neuropathy decreases the quality of life of cancer patients and leads to dose modification, discontinuation of chemotherapy, and occasionally dose-limiting toxicity. In the present case study, a 92- year-old female patient with peritoneal cancer of carcinomatous peritonitis and carcinomatous ascites was treated with carboplatin plus nab-PTX every 4 weeks as first-line chemotherapy, and a good response was achieved following 4 cycles of this regimen. However, the patient developed Grade 3 peripheral neuropathy and stopped the therapy.
View Article and Find Full Text PDF