Publications by authors named "Kousuke Takimoto"

Article Synopsis
  • Betel quid chewing, particularly due to its component arecoline, is linked to high rates of oral cancer in Southeast Asia; this study explores the effect of arecoline on specific gene expressions related to cancer development.
  • Researchers found that chronic exposure to arecoline significantly increased the expression and activity of MMP-9 in human gingival epithelial progenitor cells, indicating a potential role in cancer progression.
  • The study suggests that specific signaling pathways (NF-κB/IκB, MAPK, p38 MAPK, and STAT3) may regulate the increased MMP-9 production caused by arecoline, highlighting its importance in the pathological changes of oral tissues from betel quid use.
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