Publications by authors named "Koushiro Yoshizawa"
Article Synopsis
- MCCs (membrane-coordinated complexes) are specialized structures in yeast that contain various proteins, including the core protein Pil1, which helps maintain their function.
- Research on mutant strains lacking Pil1 and other proteins showed that the Sur7 and Nce102 families of six-tetraspan membrane proteins play distinct roles in dealing with stress and contributing to normal assembly of MCCs.
- The study revealed that the stress sensitivity in specific mutants is linked to an overactive signaling pathway involving TOR kinase complex 2 (TORC2), and that Pil1 and 6-Tsp work together to regulate this signaling during stress responses.
Article Synopsis
- Saccharomyces cerevisiae LIP1 is a part of a team that helps make special fats called sphingolipids, which are important for cell membranes.
- Scientists created a new yeast strain that could be turned off with a drug called Dox, and they found that when LIP1 was off, the yeast had trouble growing and making sphingolipids.
- The research showed that when sphingolipid levels were low, a signaling pathway called TORC2 could still activate certain proteins, which helps control how sphingolipids are made in cells.
