Publications by authors named "Koushick Sivakumar"
Nucleic Acids Res
April 2023
Article Synopsis
- The study investigates how the cellular translation system maintains homochirality (preference for L-amino acids) in proteins, emphasizing the role of enzymes like alanyl-tRNA synthetase (AlaRS).
- It challenges previous models by demonstrating that AlaRS does not activate D-alanine and that its editing domain mainly corrects errors for other amino acids, not D-alanine.
- The research provides biochemical evidence for chiral specificity, reinforcing that the recognition mechanisms ensure accurate protein synthesis and uphold the L-chiral bias in amino acids.
