Outcomes of Neoadjuvant Chemotherapy in Locally Advanced Oral Cancers: A Retrospective Analytical Study.

Introduction Head and neck cancers account for 30% of malignancies in India and oral squamous cell carcinoma is most common. 80% of the patients present with locally advanced disease and many of them are inoperable. In this study we documented the outcomes of neoadjuvant chemotherapy (NACT) in locally advanced oral cancer staged T4 with regards to downstaging the disease and to make the tumor more amenable for surgery with better access.

Transformation of Waste Toner Powder into Valuable FeO Nanoparticles for the Preparation of Recyclable Co(II)-NH-SiO@FeO and Its Applications in the Synthesis of Polyhydroquinoline and Quinazoline Derivatives.

Ecological recycling of waste materials by converting them into valuable nanomaterials can be considered a great opportunity for management and fortification of the environment. This article deals with the environment-friendly synthesis of FeO nanoparticles (composed of α-FeO and γ-FeO) using waste toner powder (WTP) calcination. FeO nanoparticles were then coated with silica using TEOS, functionalized with silane (APTMS), and immobilized with Co(II) to get the desired biocompatible and cost-effective catalyst, , Co(II)-NH-SiO@FeO.

NiFeO@B,N,F-tridoped CeO (NFTDNC): a mesoporous nanocatalyst in the synthesis of pyrazolopyranopyrimidine and 1-pyrazolo[1,2-]phthalazine-5,10-dione derivatives and as an adsorbent.

Mesoporous materials, due to their unique textural and structural features and successful applications in different scientific areas, engrossed our curiosity to form a mesoporous nanostructure. A facile method for the formation of nickel ferrite immobilized over B,N,F tridoped mesoporous cerium oxide (CeO) nanostructures (NFTDNC) was designed and communicated in this report. It was characterized by thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction study (PXRD), scanning transmission electron microscopy (STEM), high-resolution transmission electron microscopy (HR-TEM), field emission gun-scanning electron microscopy (FE-SEM), vibrating sample magnetometry (VSM), photoluminescence (PL), Brunauer-Emmett-Teller (BET), energy dispersive X-ray analysis (EDX) and elemental mapping, UV-visible spectroscopy (UV-VIS) and Fourier transform infrared spectroscopy (FT-IR).

Tick-borne Diseases in Sheep and Goats in Pakistan: A Systematic Review and Meta-analysis.

Background: Ticks are blood-sucking ectoparasites and transmit various types of protozoal, bacterial, and viral diseases in a wild as well as domestic animals and humans globally. Only a few  published reports are avaliable on the prevalence of tick-borne diseases in sheep and goats in Pakistan.

Aim And Objective: The aim of this systematic review and meta-analysis was to evaluate the prevalence (2000-2020) of tick-borne disease (theileriosis, babesiosis, Crimean-Congo hemorrhagic fever infection, and anaplasmosis) in sheep and goats in Pakistan.

Apparent Genetic Rescue of Adult Exon 21 Insertion Mutation Mice Tempered by Appropriate Control Experiments.

() is among the most common genes mutated in autism spectrum disorders (ASD) and is the causative gene in Phelan-McDermid syndrome (PMS). We performed genetic rescue of mutant phenotypes in adult mice expressing a exon 21 insertion mutation ( ). We used a tamoxifen-inducible Cre/loxP system ( ) to revert to wild-type (WT) We found that tamoxifen treatment in adult mice resulted in complete rescue of SHANK3 protein expression in the brain and appeared to rescue synaptic transmission and some behavioral differences compared to controls.

Perfluorocarbon Labeling of Human Glial-Restricted Progenitors for F Magnetic Resonance Imaging.

One of the fundamental limitations in assessing potential efficacy in Central Nervous System (CNS) transplantation of stem cells is the capacity for monitoring cell survival and migration noninvasively and longitudinally. Human glial-restricted progenitor (hGRP) cells (Q-Cells) have been investigated for their utility in providing neuroprotection following transplantation into models of amyotrophic lateral sclerosis (ALS) and have been granted a Food and Drug Administration (FDA) Investigational New Drug (IND) for intraspinal transplantation in ALS patients. Furthermore, clinical development of these cells for therapeutic use will rely on the ability to track the cells using noninvasive imaging methodologies as well as the verification that the transplanted GRPs have disease-relevant activity.

Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits.

SHANK3 (also known as PROSAP2) is a postsynaptic scaffolding protein at excitatory synapses in which mutations and deletions have been implicated in patients with idiopathic autism, Phelan-McDermid (aka 22q13 microdeletion) syndrome, and other neuropsychiatric disorders. In this study, we have created a novel mouse model of human autism caused by the insertion of a single guanine nucleotide into exon 21 (Shank3(G)). The resulting frameshift causes a premature STOP codon and loss of major higher molecular weight Shank3 isoforms at the synapse.

Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity.

Autism is a heritable disorder, with over 250 associated genes identified to date, yet no single gene accounts for >1-2% of cases. The clinical presentation, behavioural symptoms, imaging and histopathology findings are strikingly heterogeneous. A more complete understanding of autism can be obtained by examining multiple genetic or behavioural mouse models of autism using magnetic resonance imaging (MRI)-based neuroanatomical phenotyping.

Loss of predominant Shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission.

The Shank3 gene encodes a scaffolding protein that anchors multiple elements of the postsynaptic density at the synapse. Previous attempts to delete the Shank3 gene have not resulted in a complete loss of the predominant naturally occurring Shank3 isoforms. We have now characterized a homozygous Shank3 mutation in mice that deletes exon 21, including the Homer binding domain.

Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism.

We have created a mouse genetic model that mimics a human mutation of Shank3 that deletes the C terminus and is associated with autism. Expressed as a single copy [Shank3(+/ΔC) mice], Shank3ΔC protein interacts with the wild-type (WT) gene product and results in >90% reduction of Shank3 at synapses. This "gain-of-function" phenotype is linked to increased polyubiquitination of WT Shank3 and its redistribution into proteasomes.

Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation.

Background: Established traumatic memories have a selective vulnerability to pharmacologic interventions following their reactivation that can decrease subsequent memory recall. This vulnerable period following memory reactivation is termed reconsolidation. The pharmacology of traumatic memory reconsolidation has not been fully characterized despite its potential as a therapeutic target for established, acquired anxiety disorders including posttraumatic stress disorder (PTSD).

Clinical results of the intra cytoplasmic sperm injection (ICSI) at Baqai Institute of Reproduction and Developmental Sciences (BIRDS).

Objective: To analyse the results of the new revolutionary technique of Intra Cytoplasmic Sperm Injection (ICSI) for male infertility. Furthermore, to find out the ways of reducing cost of the expensive methods of Assisted Reproductive Techniques.

Design: This is an analytical study of results of 71 patients (86 Cycles) of ICSI performed in first year of its launching in Baqai Institute of Reproduction and Developmental Sciences (BIRDS) from May 1997 to April 1998.