Publications by authors named "Koung-Min Park"
Ingested microplastics (MPs) can accumulate throughout whole body, which may induce the dysfunction of immune system. However, it remains unclear how MP exposure affects innate immune responses at the cellular level. We found that mouse neutrophils strongly bind and then engulf polystyrene MPs.
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- Adipose tissue adjusts to excess calorie intake by using immune cells to replace unhealthy fat cells with new ones, particularly focusing on lipid-associated macrophages (LAMs) that are significant in obesity and inflammatory diseases.
- The study identifies TM4SF19, a protein found in LAMs, which prevents lysosome acidification; removing this protein enhances the process of clearing out damaged fat cells.
- Mice without TM4SF19 show more restorative macrophages and adapt to high-fat diets by increasing the number of fat cells (hyperplasia) instead of enlarging them (hypertrophy), leading to better insulin sensitivity and energy use as a possible strategy to fight obesity-related health issues.
Article Synopsis
- The study investigated how tumor necrosis factor (TNF)-alpha and interleukin (IL)-8 affect the expression of focal adhesion kinase (FAK) in human nucleus pulposus cells from intervertebral discs.
- * Researchers also looked at how dexamethasone impacts FAK expression when those cytokines are present.
- * Findings showed that TNF-alpha and IL-8 increase FAK expression, while dexamethasone reduces this effect, with IL-8 having a stronger influence than TNF-alpha.*
We conducted a study on the mechanism of KAI1/CD82-mediated suppression of tumor invasiveness and metastasis, and examined its effect on MMP-9 activity and the TIMP1 levels in H1299 human non-small cell lung carcinoma cells. The H1299 human lung carcinoma cells were transfected with pcDNA3.1-CD82 and stable transfectant clones that had a high KAI1/CD82 expression were obtained.
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