Plasmapheresis in severe sepsis and septic shock: a prospective, randomised, controlled trial.

Objective: To determine the therapeutic efficacy and safety of plasmapheresis in the treatment of patients with severe sepsis and septic shock.

Design: Prospective, randomised, clinical trial with a planned, midstudy, interim analysis.

Setting: Intensive care unit in a university hospital in Archangels, Russia.