Publications by authors named "Kouki Kimura"
Article Synopsis
- T cells and NK cells are important in cancer treatment, but their varying presence in tumors can limit the effectiveness of bispecific antibodies.
- The study introduces trispecific antibodies, called T cell and NK cell engagers (TaKEs), designed to recruit both T cells and NK cells simultaneously.
- Among the developed antibodies, TaKE1-Fc showed the best performance in inhibiting cancer growth and works effectively regardless of the specific populations of T and NK cells present.
Article Synopsis
- * The study focused on the 528 antibody, which is an antagonist to EGFR, and investigated its binding interactions with the soluble form of EGFR (sEGFR) through various analysis techniques like dot blotting and surface plasmon resonance.
- * Results showed that 528 targets a unique site on sEGFR, different from where other drugs like cetuximab bind, potentially making it effective against known drug-resistant mutations in EGFR.
A bispecific antibody (bsAb) is an emerging class of next-generation biological therapeutics. BsAbs are engineered antibodies possessing dual antigen-binding paratopes in one molecule. The circular backbone topology has never been demonstrated, although an enormous number of bispecific constructs have been proposed.
View Article and Find Full Text PDFLarsen syndrome is a rare congenital connective tissue disorder characterized by multiple joint dislocations. A novel anterior mediastinal tracheostomy with a median mandibular splitting approach is presented for the treatment of airway obstruction in a Larsen syndrome patient with posterior cervical arthrodesis.
View Article and Find Full Text PDFUnlabelled: The value of chemoradiation therapy (CRT) followed by surgery is unknown in Japan.
Patient And Method: Thirty Patients with TNM cStage II - III squamous cell carcinoma (SCC) of the esophagus were divided into CRT (40 Gy) followed by surgery( arm A) and definitive CRT( 60 Gy()arm B). The correlations between several clinicopathological factors and survival time were examined.
The blood oxygen level-dependent (BOLD) response to photic stimulation in the primary visual cortex (V1) reverses from positive to negative around 8 weeks of age. This phenomenon may be caused by increased oxygen consumption during stimulation as the result of a rapid increase of synaptic density at this age. To test this hypothesis, we applied existing mathematic models of BOLD signals to the experimental data from infants.
View Article and Find Full Text PDFBackground: For ambulatory pediatric outpatients,reports of abnormalities of bone metabolism associated with anti-epileptic drugs are inconsistent and may be difficult to interpret.
Methods: The effects of long-term anti-epileptic therapy (mainly valproic acid and/or carbamazepine) on bone mineral status were evaluated in ambulatory epileptic patients(seven males and 11 females) aged 5.5-15.