Introduction: Patients often take several different medications for multiple conditions concurrently. Therefore, when adverse drug events (ADEs) occur, it is necessary to consider the mechanisms responsible. Few approaches consider the mechanisms of ADEs, such as changes in physiological states.
View Article and Find Full Text PDFStud Health Technol Inform
June 2018
Disease ontology, defined as a causal chain of abnormal states, is believed to be a valuable knowledge base in medical information systems. Automatic mapping between electronic health records (EHR) and disease ontology is indispensable for applying disease ontology in real clinical settings. Based on an analysis of ontologies of 148 chronic diseases, approximately 41% of abnormal states require information extraction from clinical narratives.
View Article and Find Full Text PDFBackground: Medical ontologies are expected to contribute to the effective use of medical information resources that store considerable amount of data. In this study, we focused on disease ontology because the complicated mechanisms of diseases are related to concepts across various medical domains. The authors developed a River Flow Model (RFM) of diseases, which captures diseases as the causal chains of abnormal states.
View Article and Find Full Text PDFBackground: Recently, exchanging data and information has become a significant challenge in medicine. Such data include abnormal states. Establishing a unified representation framework of abnormal states can be a difficult task because of the diverse and heterogeneous nature of these states.
View Article and Find Full Text PDFThe RIKEN integrated database of mammals (http://scinets.org/db/mammal) is the official undertaking to integrate its mammalian databases produced from multiple large-scale programs that have been promoted by the institute. The database integrates not only RIKEN's original databases, such as FANTOM, the ENU mutagenesis program, the RIKEN Cerebellar Development Transcriptome Database and the Bioresource Database, but also imported data from public databases, such as Ensembl, MGI and biomedical ontologies.
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