Two-dimensional measurements with cut-off values are useful for assessing brain volume, physical disability, and processing speed in multiple sclerosis.

Background: Two-dimensional (2D) measures have been proposed as potential proxy measures for whole-brain volume in multiple sclerosis (MS); however, cut-off values that determine the degree of brain volume loss (BVL) have not been established. Since we had previously developed a system to categorize MS patients into clusters with significantly different degrees of BVL, we tried to identify cut-off values for 2D measurements that can discriminate MS patients on the basis of disease severity associated with brain atrophy.

Methods: In this cross-sectional analysis, ninety-one consecutive Japanese MS patients-clinically isolated syndrome (5%), relapsing-remitting MS (78%) and progressive MS (17%)-were categorized into two clusters (CL1 and CL2) with a significantly different degree of BVL using the method described in our previous study.