Comparison of preventive effect on cardiovascular events with different statins. -The CIRCLE study-.

Background: Although statins vary in their effectiveness in lowering low-density lipoprotein cholesterol (LDL-C) and increasing high-density lipoprotein cholesterol (HDL-C) levels, there is little evidence that the degree of these changes can explain cardiac risk reduction in Japan. Our objective was to compare the efficacy of statins on serum lipid levels and to explore the association between those changes and cardiac events in patients after percutaneous coronary intervention (PCI).

Methods And Results: The 743 consecutive patients who underwent PCI from 2001 to 2008 were retrospectively investigated.