Trapping and killing performance of a PermaNet 2.0 hybrid mosquito trapping bednet: an experimental hut evaluation.

Background: Despite the huge global effort , there has been an increase in malaria morbidity and mortality in sub-Saharan Africa since 2015, from 212 million cases and 429,000 deaths in 2015 to 241 million cases and 627,000 deaths in 2020 mainly because of resistance to insecticide. Therefore, advancing innovative approaches is the only sustainable way to fight malaria.

Methods: Taking advantage of the behavior of mosquitoes around the net, which is almost 70-90% concentrated on the roof, we have developed a two-compartment mosquito bednet, the so-called T-Net for mass mosquito trapping and killing.

The impact of agrochemical pollutant mixtures on the selection of insecticide resistance in the malaria vector Anopheles gambiae: insights from experimental evolution and transcriptomics.

Background: There are several indications that pesticides used in agriculture contribute to the emergence and spread of resistance of mosquitoes to vector control insecticides. However, the impact of such an indirect selection pressure has rarely been quantified and the molecular mechanisms involved are still poorly characterized. In this context, experimental selection with different agrochemical mixtures was conducted in Anopheles gambiae.

Phenotypic resistance to pyrethroid associated to metabolic mechanism in -L995F-resistant malaria mosquitoes.

The indiscriminate use of insecticides in agriculture and public health lead to a selection of resistance mechanisms in malaria vectors compromising vector control tools and strategies. This study investigated the metabolic response in the -L995F Tiassalé resistance strain after long-term exposure of larvae and adults to deltamethrin insecticide. -L995F Tiassalé strain larvae were exposed over 20 generations to deltamethrin (LS) and adults to PermaNet 2.

Multi-insecticide resistant malaria vectors in the field remain susceptible to malathion, despite the presence of Ace1 point mutations.

Insecticide resistance in Anopheles mosquitoes is seriously threatening the success of insecticide-based malaria vector control. Surveillance of insecticide resistance in mosquito populations and identifying the underlying mechanisms enables optimisation of vector control strategies. Here, we investigated the molecular mechanisms of insecticide resistance in three Anopheles coluzzii field populations from southern Côte d'Ivoire, including Agboville, Dabou and Tiassalé.

Meningeal tuberculoma mimicking a brain tumor.

Meningeal tuberculoma is one of the most serious sites of tuberculosis. Its incidence varies depending on the geographical area, rare in Western countries and frequent in developing countries where it represents 5% to 10% of intracranial masses. We report the case of a 21-year-old male patient with no particular medical history from Africa and living in Europe for more than a year, is hospitalized for an isolated inaugural, generalized, afebrile seizure in whom the scanner and cerebral magnetic resonance imaging (MRI) revealed a meningeal mass with significant glove finger edema suggesting a primary brain tumor.

Pneumonia, an Unusual Initial Presentation of Neonatal Herpes Infection.

Neonatal herpes simplex virus (HSV) infection is a life-threatening infection with high morbidity and mortality rates. Neonatal herpes, most commonly due to HSV type 2, is a multi-system disease; however, initial pulmonary presentation is extremely unusual. We describe an infant presenting with progressive respiratory distress, which was the dominant clinical feature of HSV infection during the first days of life.

Green Breast Milk Following Ingestion of Blue-Green Algae: A Case Report.

Breast milk is an excellent nutritional source for newborns, and a change in its color can be alarming to both mother and physician, and may prevent breastfeeding. Different colors of breast milk have been reported such as blood-stained, blue, and bluish-green. We present the first case of green breast milk caused by maternal ingestion of blue-green algae pills immediately before and after delivery.

Epidemiology and Antibiotic Resistance Phenotypes of Diarrheagenic Responsible for Infantile Gastroenteritis in Ouagadougou, Burkina Faso.

The emergence and persistence of multidrug-resistant (MDR) diarrheagenic (DEC) causing acute diarrhea is a major public health challenge in developing countries. The aim of this study was to evaluate the resistance phenotypes of DEC isolated from stool samples collected from children less than 5 years of age with acute diarrhea living in Ouagadougou/Burkina Faso. From August 2013 to October 2015, this study was carried out on 31 DEC strains of our study conducted in "Centre Médical avec Antenne Chirurgicale (CMA)" Paul VI and CMA of Schiphra.

First detection of N1575Y mutation in pyrethroid resistant in Southern Côte d'Ivoire.

The intensification of insecticide use for both public health and agriculture in Africa has contributed to growing insecticide resistance. Today, resistance to World Health Organization (WHO)-approved insecticide classes is widespread. In an agricultural area of Southern Côte d'Ivoire, the main malaria vector shows multiple resistance across insecticides mediated by both target site mutation and metabolic mechanisms.

First report of the East African mutation in an mosquito in Côte d'Ivoire.

. The intensive use of insecticides in public health and agriculture has led to the development of insecticide resistances in malaria vectors across sub-Saharan Africa countries in the last two decades. The target site point mutation which is among the best characterised resistance mechanisms seems to be changing its distribution patterns on the African continent.

Post-term pregnancy is an independent risk factor for neonatal morbidity even in low-risk singleton pregnancies.

Objective: To determine the independent association of post-term pregnancy with neonatal outcome in low-risk newborns.

Design: Retrospective cohort.

Setting: Tertiary university-affiliated medical centre.

The effect of gestational age on neonatal outcome in low-risk singleton term deliveries.

Objective: To assess the association between gestational age at delivery and adverse neonatal outcome among term low-risk singleton neonates.

Methods: A retrospective cohort study design was used. The study group included all low-risk singleton term (37 + 0 to 41 + 6 weeks) newborns delivered in a single tertiary university-affiliated medical center over a 5-year period.

Macrosomic newborns of non-diabetic mothers: anthropometric measurements and neonatal complications.

Objective: To assess the association of anthropometric measurements with neonatal complications in macrosomic newborns of non-diabetic mothers.

Design: Retrospective cohort study.

Patients: All liveborn, singleton, full term newborns with birth weight ≥4000 g born to non-diabetic mothers at a tertiary medical centre in 1995-2005 (n=2766, study group) were matched to the next born, healthy, full term infant with a birth weight of 3000-4000 g (control group).

Birth trauma--risk factors and short-term neonatal outcome.

Objective: The ability to predict birth trauma (BT) based on the currently recognized risk factors is limited and there is little information regarding the short-term neonatal outcome following BT. We aimed to identify risk factors for BT and to evaluate the effect of BT on short-term neonatal outcome.

Methods: A retrospective, cohort, case-control study of all cases of BT in a single tertiary center (1986-2009).

First findings on the seroepidemiology of human paragonimosis at the anti-tuberculosis centre of Divo, Repubuc of Ivory Coast (West Africa).

An epidemiological study was carried out in 2004-2005 at the anti-tuberculosis centre of Divo (Ivory Coast) to collect sera from patients who consulted for tuberculosis suspicion and to estimate the seroprevalence of human paragonimosis in the context of a systematic screening. No Paragonimus egg was found in the stools and/or sputa of the 167 persons investigated. In contrast, 41 sera were ascertained with antibodies against Paragonimus africanus using ELISA testing.

Analgesic and antiinflammatory activities of an extract from Parkia biglobosa used in traditional medicine in the Ivory Coast.

In the Ivory coast, Parkia biglobosa (Mimosaceae) is used in traditional medicine as an analgesic drug, especially against dental pain. Of the three extracts obtained from the plant bark, the hexane fraction was studied to determine its analgesic and/or antiinflammatory activities. The results show that this extract possesses a marked analgesic activity when evaluated with the abdominal writhing test in mice, but, like paracetamol, was ineffective with the hot-plate method, a feature suggesting a peripheral mechanism of action.

Additive effects of glyburide and antidepressants in the forced swimming test: evidence for the involvement of potassium channel blockade.

Evidence in the literature suggests that the modulatory effects of antidepressant drugs (ADS) on neuronal excitability, via the inhibition of K+ channels, may be the final common pathway of pharmacological action. Therefore, we tested the hypothesis that combining the ATP-sensitive K+ channel blocker glyburide with a variety of ADS would produce an additive effect and decrease the immobility time of mice in the forced swimming test (FST). Glyburide (GLY, IP, 30 and 50 mg/kg) and subactive doses of ADS were administered 45 and 30 min, respectively, prior to behavioral testing.