Publications by authors named "Kou Manabe"
New Findings: What is the central question of this study? The lack of useful small-animal models for studying exercise hyperpnoea makes it difficult to investigate the underlying mechanisms of exercise-induced ventilatory abnormalities in various disease states. What is the main finding and its importance? We developed an anaesthetized-rat model for studying exercise hyperpnoea, using a respiratory equilibrium diagram for quantitative characterization of the respiratory chemoreflex feedback system. This experimental model will provide an opportunity to clarify the major determinant mechanisms of exercise hyperpnoea, and will be useful for understanding the mechanisms responsible for abnormal ventilatory responses to exercise in disease models.
View Article and Find Full Text PDFWe aimed to develop a novel method to quantitatively evaluate the effects of odor stimulation on cardiorespiratory functions over time, and to examine the potential usefulness of clinical aromatherapy. Eighteen subjects participated. Nine people were assigned to each of the two resting protocols.
View Article and Find Full Text PDFPeriodic Breathing in Heart Failure Explained by Dynamic and Static Properties of Respiratory Control.
Clin Med Insights Cardiol
November 2015
Article Synopsis
- The study investigates how the respiratory control system operates by analyzing the interaction between its controller and plant elements, focusing on understanding respiration regulation and periodic breathing in chronic heart failure.
- Researchers measured the relationship between arterial CO2 levels and minute ventilation in healthy individuals to derive dynamic properties, concluding that both controller and plant behaviors can be modeled mathematically.
- An instability in the respiratory system can lead to periodic breathing when abnormalities in the chemoreflex system amplify control system instability.