Publications by authors named "Kotze I"

Due to the COVID-19 pandemic, many children missed their routine vaccinations globally. There is insufficient evidence on the trends in vaccination coverage in the private healthcare sector in South Africa. This study explored the changes in childhood vaccination patterns (non-COVID vaccines) in the private healthcare sector in South Africa using medicine claim data.

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This study addresses the pressing issue of depleting natural resources of platinum group metals (PGMs), driven by their widespread use in modern applications and increasing demand for renewable energy technologies. With conventional sources dwindling, the search for economically viable recovery methods from alternative sources has become crucial. Our focus was on innovating efficient recovery strategies, leading to the development of two novel silica-anchored adsorbents: DTMSP-BT-SG, a highly efficient acylthiourea adsorbent, and BTMSPA-SG, a silica-anchored amine adsorbent.

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In this study, zeolitic imidazolate frameworks (ZIF) were employed as effective porous supports for laccase enzyme attachment and further explored synergistic adsorption and biocatalytic degradation of carbamazepine (CBZ) in aqueous solutions. Characterization results from FTIR and NMR analysis confirmed successful incorporation of the laccase enzyme onto ZIF particles. Further analyses from SEM and TEM revealed rhombic dodecahedral morphologies of ZIF crystals with crusts of the enzyme observed on the particles' surface.

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Despite the concerted efforts to develop targeted cancer treatments, these therapies are plagued by the rapid development of resistance and serious adverse drug reactions. Based on the wide clinical use and successes of the platinum drugs like cisplatin and oxaliplatin, we investigated the synthesis and potential anticancer efficacy of alternative platinum complexes. A series of nine cationic square planar platinum(ii) complexes were synthesized and characterized and then evaluated for their anticancer activity.

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Background: The magnitude of the incidence and impact of nausea on patients receiving intravenous chemotherapy seems to be underestimated by healthcare professionals. Development of effective anti-emetic treatment has contributed to the resolution of chemotherapy-induced nausea and vomiting (CINV). However, there is a concern that vomiting has been the initial focus of anti-emetic research and nausea was perceived as a secondary endpoint.

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Classical hydroformylation catalysts use mononuclear rhodium(I) complexes as precursors; however, very few examples of bimetallic systems have been reported. Herein, we report fully substituted dirhodium(II,II) complexes (-) containing acetate and diphenylformamidinate bridging ligands (-). The structure and geometry around these paddlewheel-type, bimetallic cores were confirmed by single-crystal X-ray diffraction.

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Background: The South African (SA) private medical schemes environment has over the past two decades respond to the evolving needs of people living with the human immunodeficiency virus (PLWH) or acquired immunodeficiency syndrome (AIDS).

Objective: To determine changes in the incidence and prevalence rate of human immunodeficiency virus (HIV) or AIDS in the SA private medical schemes environment from 2005 to 2015.

Method: In this observational study, a single, pharmaceutical benefit management (PBM) company's medicine-claims database of members with HIV or AIDS has been retrospectively analysed from January 2005 to December 2015.

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There is a need for cheap but, efficient methods for the removal of precious metals from wastewaters, which are normally lost during mineral processing. Moreover, the disposal of yeast waste from brewing has been a problem in many parts of the world. In this study, the removal of Pt(IV) from aqueous solutions using the readily available bentonite clay functionalised with spent yeast from brewing was investigated.

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(1)H NMR chemical shift concentration dependence as well as the diffusion coefficients from DOSY NMR of mixed ligand [Pt(II)(1,10-phenanthroline)(N-pyrrolidyl-N-(2,2-dimethylpropanoyl)thiourea)]Cl ([Pt(II)(phen)(L(1)-S,O)]Cl) dissolved in mixtures of acetonitrile-water in the range 0-30% (v/v) D(2)O-CD(3)CN shows that the complex cation (M(+) = [Pt(II)(phen)(L(1)-S,O)](+)) aggregates to form dimers, 2M(+) ⇌ {M(+)}(2), with association constants ranging from K(D)(CD(3)CN) = 17 ± 2 M(-1) to K(D)(30% (v/v) D(2)O-CD(3)CN) = 71 ± 8 M(-1) at 299.3 K, presumably via non-covalent cation-π interactions. Experimental data are consistent with an 'offset' face-to-face cation-π stacking arrangement of the planar cation.

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Objective: To determine the prevalence of Lactobacillus spp. in vaginal flora during pregnancy and to assess the protective effects of lactobacilli against preterm labour.

Design: Cross-sectional analysis of Lactobacillus spp.

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