Multifaceted bioactivity of marine fungal derived secondary metabolite, xyloketal B -a review.

Background: A growing number of findings have focused on the distinctive physiochemical characteristics that marine microorganisms have acquired as a result of their adaptation to the challenging conditions inherent in the marine environment. It has been established that the marine environment is a very rich source of bioactive substances with a variety of biological effects and structural diversity. A major discovery was the extraction of xyloketals from sp.

Mechanism of protection of rat hepatocytes from acetaminophen-induced cellular damage by ethanol extract of .

The aim of this study is to evaluate the protective effect of ethanol extract of (EEAL) in preventing acetaminophen induced liver toxicity. EEAL was prepared and its hepatoprotective effect was studied in both isolated primary hepatocytes and in Sprague Dawley rats . For studies, the animals were grouped as Group I - Control; Group II - ACN (2 g/kg b.

p-Coumaric acid mediated protection of H9c2 cells from Doxorubicin-induced cardiotoxicity: Involvement of augmented Nrf2 and autophagy.

Doxorubicin (Dox) is a widely administered chemotherapeutic drug and incidences of cardiotoxicity associated with its administration have been of general concern. Extensive research proposes several mechanisms as a cause of Dox induced cardiotoxicity. However, none of these studies have been able to suggest a find one, cure all antidote for the same.

Protective effect of -coumaric acid against doxorubicin induced toxicity in H9c2 cardiomyoblast cell lines.

Doxorubicin (Dox) has been used for more than four decades to treat cancer, particularly solid tumours and haematological malignancies. However, the administration of this drug is a matter of concern in the clinical community, since Dox therapy is commonly associated with dose-dependent cardiotoxicity. Attempts at alleviating drug generated cardiac damage using naturally occurring compounds with radical scavenging property are a promising area of research.

Coconut kernel-derived proteins enhance hypolipidemic and antioxidant activity in alloxan-induced diabetic rats.

Impaired lipid levels and oxidative stress are indicative of malfunction of endogenous antioxidant capacity. The aim of this study was to determine the effect of coconut kernel protein (CKP) on the lipid peroxides and antioxidant enzyme activities in diabetic rats. Diabetes was induced prior to feeding by injecting a single dose of alloxan (150 mg/kg body weight) intraperitoneally.

Arginine-rich coconut kernel diet influences nitric oxide synthase activity in alloxandiabetic rats.

Background: Coconut kernel protein (CKP) has been reported to contain significant amounts of L-arginine. Its potential effect on glucose homeostasis, possibly through the nitric oxide synthase (NO) pathway, was therefore investigated in alloxan-induced diabetic rats. Diabetes was induced by a single intraperitoneal dose of alloxan (150 mg kg⁻¹ body weight).

A small oxazine compound as an anti-tumor agent: a novel pyranoside mimetic that binds to VEGF, HB-EGF, and TNF-α.

A novel pyranoside mimetic compound, DMBO (2-(2,6-difluorophenyl)-5-(4-methoxyphenyl)-1-oxa-3-azaspiro[5.5]undecane), was designed and synthesized. The sugar mimicking behavior of DMBO was addressed by its ability to bind several growth factors/cytokines such as vascular endothelial growth factor (VEGF), heparin-binding epidermal growth factor-like growth factor (HB-EGF), and tumor necrosis factor (TNF)-α as demonstrated by the recently developed surface plasmon resonance assay.