Neurological symptoms, genotype-phenotype correlations and ethnic-specific differences in Bulgarian patients with Wilson disease.

Objectives: The aim of our study was to characterize the neurological symptoms in Bulgarian patients with Wilson disease (WD), to investigate genotype-phenotype correlations, and to test whether there are differences in phenotype between patients of different ethnic origin.

Patients And Methods: A total of 126 Bulgarian patients with WD were included in the study. Detailed history, physical and neurological examination, laboratory investigation of copper metabolism, slit-lamp examination, abdominal ultrasound, magnetic resonance imaging/computed tomography of the brain, molecular genetic testing, and statistical analysis were performed.

[The role of polyclonal anti-T-lymphocyte antibodies (ATG) in the kidney transplantation].

Unlabelled: The successes in the kidney transplantation are closely connected with the successes of the immunology and the advance of the immunosuppressive therapy. The main task of the modern immunosuppressive therapy is the insurance of medicines with a minimum nephro-toxicity, and the optimum protection regarding the adoptive body against an early reaction of rejection. The polycomponent anti-T-limphocitic antibodies (ATG) give us the opportunity of that.

[Treatment with cefrom (cefpirom) in severe urological infections].

Severe uro-genital infections frequently complicate a wide range of urological conditions. The favorable outcome of these infections depends mainly on the choice of appropriate antimicrobial treatment. Cefrom is bactericidal beta-lactamase-resistant IV generation cephalosporine antibiotic.

[Blue sclera in iron deficiency conditions].

The study involved 91 inpatients with anemia or/and blue sclera. Of them 66 proved iron-deficient: 59 with blue sclera against 7 without such. Twenty-three anemic patients free of iron-deficiency included 9 patients with blue sclera and 16 without them.

[The diagnostic value of echography in hepatic echinococcosis].

The ultrasound method of examination led to revolutionary changes in the diagnosis of liver echinococcosis [correction of Echinococcus]. The ultrasound image of this disease, which is common in the region, is presented. The ultrasound method is compared with other diagnostic methods and its importance is pointed out.

[Endoscopic assessment of hemorrhage from the gastrointestinal tract].

The causes of gastrointestinal bleedings was assessed by fiber gastroscopy, rectoromanoscopy and fiber colonoscopy. The most frequent causes of bleedings from the upper gastrointestinal tract are gastric and duodenal ulcers, erosive hemorrhagic gastritis, gastric cancer, liver cirrhosis with bleeding from varicose veins, polyps, diverticuli, Mallory-Weiss syndrome, etc. The most frequent causes of bleedings from the lower gastrointestinal tract are hemorrhoids, anal fissures, colonic polyps, chronic ulcerohemorrhagic colitis, rectal carcinoma, etc.

[The incidence of duodenogastric reflux and its relation to stomach and duodenal diseases].

The data available in the literature on the incidence of duodenogastric reflux and its relation with diseases of the stomach and duodenum are controversial. A study was performed based on the results of 4256 primary endoscopies of the stomach and duodenum: 3673 in nonoperated patients and 583 in patients having undergone vagotomy and resection. For duodenogastric reflux one judged from the yellow coloration of the gastric juice and regurgitation of bile at the moment of examination.

[Comparative fiber colonoscopic and x-ray studies in diseases of the large intestine].

For a two year period 79 patients were examined by fiber colonoscopy and X-ray examination of the colon. The purpose of the study is to find out the sensitivity, specificity and accuracy of the methods for the diagnosis of the most frequent diseases of the colon. The results allow the conclusion that fiber colonoscopy is the method of choice in the diagnosis of the neoplasms and the inflammatory diseases of the colon.