PATHOGENETIC FEATURES OF COMORBIDITY OF PRIMARY OSTEOARTHRITIS AND DISEASES WITH EXOCRINE PANCREATIC INSUFFICIENCY.

The aim of the study - to study the pathogenetic effects of activation of the kallikrein-kinin system on the course of primary osteoarthritis under conditions of comorbidity with gastroenterological diseases accompanied by exocrine pancreatic insufficiency.We examined 229 patients with primary osteoarthritis in comorbidity with exocrine pancreatic insufficiency at diseases of the gastrointestinal tract without exacerbation. The parameters of the kallikrein-kinin system and their influence on the course of primary osteoarthritis and comorbid nosologies of the gastrointestinal tract were studied.

The effect of the proteolisis' system activity for the trophological status of patients with osteoarthrosis and excretory insufficiency of pancreas.

Objective: Introduction:The excretory insufficiency of pancreas in patients with primary osteoarthrosis is formed at the comorbid pathologies and as a result of long-term treatment of osteoarthrosis using the non-steroidal anti-inflammatory drugs, steroids, chondroprotectors and chondrostimulators etc. The aim: to study the state of the proteolysis system and immune status, the presence and depth of the dysbiosis of colon in patients with primary osteoarthrosis against a violation of their excretory insufficiency of pancreas.

Patients And Methods: Materials and methods: There were 64 outpatients with primary OA (group 1) and 74 patients with primary OA in combination with diseases associated with EIP (group 2).

Improvement of the complex medical treatment for the patients wіth chronic biliary pancreatitis.

Introduction: The most common reason of chronic pancreatitis is liver and bile ducts disease: functional disorders, chronic cholecystitis, cholelithiasis and cholecystectomy in medical history. All these changes are associated with the colloidal structure of bile, increased lithogenicity, gallstones formation, Oddi's sphincter dysfunction, dysmotility and inflammation in the bile ducts.

The Aim: to study the effectiveness of using medicine Liveria IC (metadoxine) in standard therapy as well as effect on spectrum of blood serum lipids and structural condition of liver (stiffness) and pancreas in patients with chronic biliary pancreatitis combined with obesity.