Publications by authors named "Kotryna Diktonaite"
Article Synopsis
- Native Hawaiian and Pacific Islander (NHPI) adults have historically been grouped with Asian adults in mortality data, but since 2018, they've been reported separately, allowing better insights into their health statistics.
- From 2018 to 2022, NHPI adults experienced 10,870 deaths from cardiovascular disease (CVD), with a mortality rate of 369.6 deaths per 100,000, which is significantly higher than the rate for Asian adults (243.9 per 100,000).
- The study highlights the need for further research into NHPI health issues since their high CVD mortality rate was previously obscured when grouped with Asian populations.
Aging is a key independent risk factor of various vascular diseases, for which the regulatory mechanisms remain largely unknown. Bromodomain-containing protein 4 (BRD4) is a member of the Bromodomain and Extra-Terminal domain (BET) family and is an epigenetic reader playing diverse roles in regulating transcriptional elongation, chromatin remodeling, DNA damage response, and alternative splicing in various cells and tissues. While BRD4 was initially recognized for its involvement in cancer progression, recent studies have revealed that the aberrant expression and impaired function of BRD4 were highly associated with aging-related vascular pathology, affecting multiple key biological processes in the vascular cells and tissues, providing new insights into the understanding of vascular pathophysiology and pathogenesis of vascular diseases.
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