Publications by authors named "Kotori Mawatari"
Clinical significance of acidic extracellular microenvironment modulated genes.
Front Oncol
September 2024
Article Synopsis
- The study explored how different levels of acidic pH (pH 6.8 and pH 5.9) impact gene expression in B16-BL6 melanoma cells and compared these effects to similar patterns in human tumors.
- A cDNA microarray analysis was conducted to identify changes in mRNA expression, revealing that pH significantly influences which genes are expressed or suppressed in these cells.
- The findings indicate that acidic pH modulates gene expression differently across various cancer types, notably impacting prognosis in colorectal, lung, and head and neck cancers, while showing lesser effect in prostate cancer.