Publications by authors named "Kotomi Sato"
Article Synopsis
- Chronic inflammation is linked to the growth and worsening of colorectal cancer (CRC), prompting research on the underlying molecular mechanisms.
- In vivo screening revealed 142 frequently mutated genes in inflammation-associated colon tumors, highlighting the role of senescence and TGFβ-activin signaling pathways.
- The study identifies potential therapeutic targets, such as the Cdk4/6 inhibitor and tumor suppressor genes Arhgap5 and Mecom, emphasizing the significance of senescence pathway inactivation in CRC within inflammatory environments.
Precise analysis of tissue DNA and RNA samples is often hampered by contaminating non-target cells whose amounts are highly variable. DNA methylation profiles are specific to cell types, and can be utilized for assessment of the fraction of such contaminating non-target cells. Here, we aimed 1) to identify methylation profiles specific to multiple types of mouse leukocytes, and 2) to estimate the fraction of leukocytes infiltrating inflamed tissues using DNA samples.
View Article and Find Full Text PDFEarly detection of doxorubicin (DXR)-induced cardiomyopathy (DXR-ICM) is crucial to improve cancer patient outcomes and survival. In recent years, the intraventricular pressure gradient (IVPG) has been a breakthrough as a sensitive index to assess cardiac function. This study aimed to evaluate the usefulness of IVPG for the early detection of chemotherapy-related cardiac dysfunction.
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- Vorticity is a new measure that helps assess how well the left ventricle of the heart functions during the diastolic phase, which is when the heart fills with blood.
- The size of the ventricle can greatly affect how blood flows during this filling phase, and the study evaluated this impact using a variety of dog breeds with different body sizes.
- Results showed that vorticity decreases as the ventricular chamber length increases, indicating that size plays a crucial role in diastolic function, highlighting the importance of considering ventricular size in both veterinary medicine and pediatric cardiology.
Left ventricular vortex and intraventricular pressure difference in dogs under various loading conditions.
Am J Physiol Heart Circ Physiol
April 2019
Restrictions on the conventional evaluation of diastolic function have been recognized, especially under various loading conditions. Recently, new noninvasive ventricular vortex indexes have been introduced and are expected to reflect the cardiac function. Physiologically, there is a hypothesis that the intraventricular pressure difference (IVPD) is related to the formation of vortexes.
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