Modulation of doxorubicin-induced genotoxicity by Aegle marmelos in mouse bone marrow: a micronucleus study.

The effect of various concentrations of Aegle marmelos (AME) on the doxorubicin (DOX)-induced genotoxic effects in mice bone marrow was studied. Treatment of mice with different concentrations of DOX resulted in a dose-dependent elevation in the frequency of micronucleated polychromatic (MPCE) as well as normochromatic (MNCE) erythrocytes in mouse bone marrow. The frequencies of MPCE and MNCE increased with scoring time, and the greatest elevation for MPCE was observed at 48 hours post-DOX treatment, whereas a maximum increase in MNCE was observed at 72 hours post-DOX treatment.

REMOVED: Inhibition of doxorubicin-induced clastogenic effect by Aegle marmelos (L.) correa in cultured V79 cells.

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Carcinoma of external auditory canal.

Tumors of external auditory canal are rare and malignant neoplasms of external auditory canal are uncommon. We report two cases of carcinoma of external auditory canal. Primary carcinomas of the external auditory canal are rare, the incidence being approximately two cases per one million per year.

Osteosarcoma of facial bones.

Osteosarcoma, involving mandible and zygoma in 3 patients is presented and discussed; their clinical, radiological and treatment results are detailed. As this disease is uncommon in these bones, the difficulty in the management merits attention.