Publications by authors named "Kotaro Takeno"
Antioxidants (Basel)
November 2024
Article Synopsis
- * A study on mice with reduced mitochondrial superoxide dismutase (SOD2) showed that a lack of this enzyme led to increased muscle glycogen and motor dysfunction, indicating a link between mitochondrial health and muscle performance.
- * The research found that the enzyme responsible for breaking down glycogen (GP-M) was less active in these mice and could be restored by antioxidants, suggesting that maintaining mitochondrial redox balance is crucial for proper glycogen metabolism and muscle function.
Article Synopsis
- * This study analyzed the effects of aging on sympathetic nerves and synaptic proteins in mouse neuromuscular junctions using immunohistochemistry, focusing on age-related changes in different age groups and those treated with nicotinamide mononucleotide (NMN).
- * While sympathetic nerve markers remained unchanged with age, there was a significant decline in presynaptic and postsynaptic proteins, which could be restored to adult levels with NMN treatment, highlighting a potential therapeutic avenue against age-related declines.
