Publications by authors named "Kota Shoji"
Article Synopsis
- Acute myeloid leukemia (AML) involves the halted development of blood cell precursors, with limited differentiation therapies available outside acute promyelocytic leukemia.
- A study evaluated seven benzimidazole anthelmintics, finding that most increased expression of monocyte markers in AML cells, with parbendazole (PBZ) being particularly effective at inducing differentiation, gene expression changes, and cell death.
- In tests with a mouse model of AML, PBZ treatment significantly reduced disease progression and improved survival, suggesting potential for better differentiation therapies in AML patients.
