Publications by authors named "Kota Momose"
DNA methylation is known to be involved in tumor progression. This is the first study to perform an extensive methylation analysis of plasma circulating tumor DNA (ctDNA) using targeted bisulfite sequencing in gastric cancer (GC) patients to evaluate the usefulness of ctDNA methylation as a new biomarker. Sixteen patients who received chemotherapy for recurrent GC were included.
View Article and Find Full Text PDFBackground: Various techniques have been used to prevent smudge on a laparoscope when inserting through trocars; however, there has been no standardized method. The purpose of this study was to compare the performance of different cleaning techniques with or without using dedicated devices, and to evaluate the features of cleaning devices.
Methods: The smudge was created in the standard 12-mm and 5-mm ports using pseudo-blood, and port cleaning was attempted using 5 different methods: (1) a surgical gauze + surgical forceps, (2) a surgical gauze + laparoscopic forceps, (3) a small laparoscopic gauze + laparoscopic forceps, (4) a cylinder-type cleaner (Endo Wiper; Osaki Medical), and (5) a swab-type cleaner (Port Cleaner; Hakuzo Medical).
Article Synopsis
- Postoperative delirium is a common issue in elderly patients after gastric cancer surgery, affecting about 12.2% of those studied.
- The study analyzed 255 patients aged 75 and older, linking factors like poor Eastern Cooperative Oncology Group performance status (ECOG-PS), diabetes, and mental decline to higher delirium rates.
- The researchers found that combining scores from the Mini-Mental State Examination (MMSE) and ECOG-PS can predict delirium effectively, with 80.7% sensitivity and 74.1% specificity.
Background: Lipolysis-stimulated lipoprotein receptor (LSR), a lipid receptor, is associated with cancer progression. However, detailed effects on intracellular metabolism are unclear. We aimed to elucidate the mechanism of LSR-mediated lipid metabolism in gastric cancer.
View Article and Find Full Text PDFBackground: The association between recurrence timing and prognosis in patients with locally advanced resectable esophageal cancer undergoing neoadjuvant chemotherapy (NAC) followed by esophagectomy remains unclear. This study aimed to clarify this association using multicenter prospective clinical trial data.
Methods: Among 162 patients enrolled in a NAC phase II study comparing the efficacy of cisplatin and fluorouracil plus docetaxel with cisplatin and fluorouracil plus adriamycin, 64 patients with recurrence after R0 resection were included in this study.
Article Synopsis
- * Imaging showed that part of his gastrointestinal tract had moved into the chest cavity, leading to the diagnosis of a diaphragmatic hernia, which required surgery.
- * During the surgery, a 12x8 cm hernia was found, and traditional mesh repair was deemed insufficient, prompting the use of a myocutaneous flap from the left rectus abdominis to successfully close the defect.
Objective: Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are inflammatory cytokines produced in response to biological invasion or infection. Their levels are elevated in the blood and locally. We examined whether measuring IL-6 and TNF-α levels in serum or drainage fluid on postoperative day (POD) 1 could detect infectious complications after minimally invasive surgery for gastric cancer.
View Article and Find Full Text PDFBackground/aim: Most clear cell renal cell carcinomas (ccRCCs) have a dysfunctional von Hippel-Lindau tumor suppressor protein (VHL). Hypoxia-inducible factors 1 and 2 alpha (HIF1α and HIF2α) accumulate in ccRCC with dysfunctional VHL and up-regulate the vascular endothelial growth factor (VEGF) pathway and tumor angiogenesis. Recently, pimitespib (PIM), a potent ATP-competitive inhibitor of heat shock protein 90 (HSP90), was developed.
View Article and Find Full Text PDFPurpose: Suprapancreatic lymph node dissection is one of the most challenging procedures performed in the treatment of gastric cancer. This study aimed to investigate whether the pancreas-left gastric artery angle (PLA) can be used to predict the difficulty of the procedure.
Methods: This was a single-center cross-sectional study.
Article Synopsis
- This study evaluated the real-world effectiveness of nivolumab, a cancer treatment, in patients with advanced esophageal squamous-cell carcinoma (ESCC) who had recurrent or unresectable disease.
- Results showed that while the objective response rate to nivolumab was 17% with a disease control rate of nearly 48%, the median overall survival was about 10.9 months, indicating limited long-term effectiveness.
- Key prognostic factors identified included performance status and the C-reactive protein-to-albumin ratio, which can help healthcare providers predict patient outcomes more accurately.
Background: Multidisciplinary treatment combining chemotherapy, chemo radiation therapy (CRT), and surgery has been utilized for advanced esophageal cancer. However, preoperative treatment could cause postoperative inflammation and complications. We hypothesized that fibrosis surrounding tumor tissue caused by preoperative treatment could induce postoperative systemic inflammation and influence postoperative complications.
View Article and Find Full Text PDFBackground: The standard treatment for advanced esophageal cancer with synchronous distant metastasis is systemic chemotherapy or immunotherapy. Conversion surgery is not established for esophageal cancer with synchronous distant metastasis. This study aimed to investigate the clinical impact of conversion surgery for esophageal cancer with synchronous distant metastasis after induction therapy.
View Article and Find Full Text PDFArticle Synopsis
- A diaphragmatic hernia occurs when abdominal organs push through a hole in the diaphragm, typically due to trauma, which can delay symptoms and lead to severe complications over time.
- A case study involved a 64-year-old man who experienced colon incarceration from a left diaphragmatic hernia, initially refusing surgery despite repeating symptoms for 14 months, before finally opting for laparoscopic repair.
- The patient had a successful surgical outcome, with no recurrence of the hernia observed seven months post-operation.
Background: Severe scoliosis can cause reflux esophagitis, and is a risk factor for Barrett's adenocarcinoma of the esophagus. Severe scoliosis is associated with respiratory dysfunction, impaired operative tolerance, and anatomical difficulty in surgical manipulation, and is, therefore, considered a high surgical risk. In this report, we describe the case of a young patient with Barrett's esophageal adenocarcinoma with severe scoliosis who underwent salvage surgery after radical chemoradiotherapy.
View Article and Find Full Text PDFPurpose: To investigate the indications for neoadjuvant chemotherapy (NAC) in esophageal cancer patients aged 75 years or older.
Methods: We analyzed data, retrospectively, from 155 patients over 75 years old, who underwent esophagectomy for esophageal cancer between 2010 and 2020. Forty-one patients underwent upfront surgery (US group) and 114 were treated with NAC followed by surgery (NAC group).
Article Synopsis
- Body weight loss (BWL) is a serious issue after gastrectomy in gastric cancer patients, and current nutritional interventions aren't sufficient to address it.
- This study involved 60 patients and evaluated their masticatory ability using functional tooth units (FTU), finding that those with fewer than 4 FTU experienced significantly more weight loss after surgery.
- The research concluded that low FTU counts are an independent risk factor for greater BWL post-gastrectomy, suggesting that improving oral health may enhance nutritional status after surgery.
Background: The treatment efficacy of immune checkpoint inhibitors (ICIs) is limited, and biomarkers that identify responders are urgently needed. We investigated whether C-reactive protein (CRP) kinetics are associated with the treatment efficacy of ICIs and prognosis in oesophagogastric cancers.
Methods: We analysed 76 gastric cancer patients treated with nivolumab monotherapy.
Intraperitoneal chemotherapy, in which an anticancer drug is administered directly into the abdominal cavity through an intraperitoneal access port(IP port), is one of the treatment options for advanced gastric cancer with peritoneal metastasis. Herein, we report a case of sheath-like obstruction of the entire catheter of the IP port due to tissue reaction within a short period of time after IP port implantation. The case was a 35-year-old woman with advanced type 4 gastric cancer with peritoneal dissemination.
View Article and Find Full Text PDFIntroduction: This study aimed to clarify the impact of the average relative dose intensity (RDI) of neoadjuvant chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (DCF-NAC) for resectable locally advanced esophageal squamous cell carcinoma (ESCC).
Materials And Methods: To identify the optimal RDI, recurrence-free survival (RFS) and cumulative incidence function (CIF) for recurrence were calculated in low and high RDI groups with any cut-off points. The optimal RDI was defined as the highest RDI administered with a significant increase in either RFS or CIF.
Background: Ghrelin has been reported to reduce postoperative weight loss by improving appetite and food intake in patients undergoing upper gastrointestinal surgery.
Objective: We aimed to investigate whether growth hormone induction, another essential effect of ghrelin, may attenuate skeletal muscle loss in patients during postoperative starvation.
Methods: Esophageal cancer patients were randomized to receive a continuous intravenous infusion of high-dose ghrelin (HD; 0.
Background: This study was performed to verify the superiority of a new "non-tensioning method" for avoiding stricture of the cervical esophagogastric anastomosis by circular stapling compared with the conventional method.
Methods: In total, 395 consecutive patients who underwent McKeown esophagectomy with gastric conduit (GC) reconstruction were reviewed. A 4 cm-wide GC was created and pulled up at the cervical site through the retrosternal route.
Purpose: The prognosis of gastric cancer patients with peritoneal metastasis (PM) remains dismal with standard systemic chemotherapy. Intraperitoneal (i.p.
View Article and Find Full Text PDFBackground: The THUNDERBEAT is a multi-functional energy device which delivers both ultrasonic and bipolar energy, but there are no randomized trials which can provide more rigorous evaluation of the clinical performance of THUNDERBEAT compared to other energy-based devices in colorectal surgery. The aim of this study was to compare the clinical performance of THUNDERBEAT energy device to Maryland LigaSure in patients undergoing left laparoscopic colectomy.
Methods: Prospective randomized trial with two groups: Group 1 THUNDERBEAT and Group 2 LigaSure in a single university hospital.