Initiation of Psychotropic Drugs in Spouses of Patients With Early-Onset Alzheimer's Disease: A Matched Cohort Study.

Objectives: The diagnosis of early-onset Alzheimer's disease (EOAD) can cause emotional stress not only to the patients themselves but also to their spouses. This study aimed to evaluate the risk of psychiatric disorders in spouses of EOAD patients, using psychotropic drug initiation as a surrogate indicator.

Methods: A cohort study was conducted using a Japanese claims database, with spouses of EOAD patients (exposed spouses) matched with spouses of non-EOAD individuals (reference spouses) up to a 1:10 ratio.

Oxoammonium salts exert antiviral effects against coronavirus via denaturation of their spike proteins.

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV2) infection has forced social changes worldwide. Development of potent antiviral agents is necessary to prevent future pandemics. Titanium oxide, a photocatalyst, is a long-acting antiviral agent; however, its effects are weakened in the dark.

Thermally Reentrant Crystalline Phase Change in Perovskite-Derivative Nickelate Enabling Reversible Switching of Room-Temperature Electrical Resistivity.

Reversible switching of room-temperature electrical resistivity due to crystal-amorphous transition is demonstrated in various chalcogenides for development of non-volatile phase change memory. However, such reversible thermal switching of room-temperature electrical resistivity has not reported in transition metal oxides so far, despite their enormous studies on the electrical conduction like metal-insulator transition and colossal magnetoresistance effect. In this study, a thermally reversible switching of room-temperature electrical resistivity is reported with gigantic variation in a layered nickelate Sr Bi NiO (1201-SBNO) composed of (Sr Bi )O rock-salt and SrNiO perovskite layers via unique crystalline phase changes between the conducting 1201-SBNO with ordered (O-1201), disordered Sr/Bi arrangements in the (Sr Bi )O layer (D-1201), and insulating oxygen-deficient double perovskite Sr BiNiO (d-perovskite).

Increased hole mobility in anti-ThCrSi-type LaOBi co-sintered with alkaline earth metal oxides for oxygen intercalation and hole carrier doping.

Metallic anti-ThCrSi-type REOBi (RE = rare earth) with Bi square nets show superconductivity while insulating LaOBi shows high hole mobility, by expanding the c-axis length through oxygen intercalation. In this study, alkaline earth metal oxides (CaO, SrO and BaO) were co-sintered with LaOBi. CaO and BaO served as oxygen intercalants without the incorporation of Ca and Ba in LaOBi.

Tetragonality induced superconductivity in anti-ThCrSi-type REOBi (RE = rare earth) with Bi square nets.

We report a series of layered superconductors, anti-ThCrSi-type REOBi (RE = rare earth), composed of electrically conductive Bi square nets and magnetic insulating REO layers. Superconductivity was induced by separating the Bi square nets as a result of excess oxygen incorporation, irrespective of the presence of magnetic ordering in REO layers. Intriguingly, the transition temperature of all REOBi including nonmagnetic YOBi was approximately scaled by unit cell tetragonality (c/a), implying a key role in the relative separation of the Bi square nets to induce superconductivity.