Ypaoamides B and C, Linear Lipopeptides from an Okeania sp. Marine Cyanobacterium.

Two new pyrrolinone-containing lipopeptides, ypaoamides B (1) and C (2), were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. Their structures were determined by spectroscopic analysis and Marfey's analysis of acid hydrolysates.

Three New Malyngamides from the Marine Cyanobacterium Moorea producens.

Three new compounds of the malyngamide series, 6,8-di--acetylmalyngamide 2 (), 6--acetylmalyngamide 2 (), and -demethyl-isomalyngamide I (), were isolated from the marine cyanobacterium . Their structures were determined by spectroscopic analysis and chemical derivatization and degradation. These compounds stimulated glucose uptake in cultured L6 myotubes.

Total synthesis of odoamide, a novel cyclic depsipeptide, from an Okinawan marine cyanobacterium.

Odoamide is a novel cyclic depsipeptide with highly potent cytotoxic activity isolated from the Okinawan marine cyanobacterium Okeania sp. It contains a 26-membered macrocycle composed of a fatty acid moiety, a peptide segment and isoleucic acid. Four possible stereoisomers of the odoamide polyketide substructure were synthesised using a chiral pool approach.

Kanamienamide, an Enamide with an Enol Ether from the Marine Cyanobacterium Moorea bouillonii.

Kanamienamide, an enamide with an enol ether, was isolated from the marine cyanobacterium Moorea bouillonii. The gross structure was established by spectroscopic analyses, and the relative stereochemistry was elucidated on the basis of the analyses of NOESY correlations and H-H coupling constants. The absolute configuration was determined on the basis of the chiral HPLC analysis of the N-Me-Leu derived from kanamienamide.