Publications by authors named "Kosuke Kambe"
Article Synopsis
- This study evaluates a new type of mesenchymal stem cells (MSCs) that produce antibodies targeting the GD2 antigen found on neuroblastoma (NB) cells, aimed at enhancing antitumor effects.
- The researchers created a construct that enables MSCs to secrete these anti-GD2 antibodies, confirming their effectiveness through techniques like Western blotting and flow cytometry.
- Results demonstrate that the anti-GD2-MSCs have a high transduction rate and significantly boost the ability of natural killer (NK) cells to kill NB cells, suggesting their potential use in treating resistant neuroblastoma.
Article Synopsis
- Researchers developed mouse mesenchymal stem cells (MSCs) that secrete antibodies targeting the disialoganglioside GD2, and tested their effectiveness against neuroblastoma in mouse models.
- They used a specific process to create the anti-GD2 antibody constructs and introduced them into the MSCs, then evaluated their impact on tumor growth and immune response.
- The results indicated that these engineered anti-GD2-MSCs significantly inhibited tumor growth and increased the infiltration of natural killer cells, suggesting potential for a new immunotherapy approach for difficult-to-treat neuroblastoma.
Article Synopsis
- The study investigates complications, specifically gastroesophageal reflux disease (GERD), following the surgical repair of esophageal atresia (EA) in children, aiming to identify predictive factors for the need for anti-reflux surgery.
- Researchers analyzed data from 65 EA patients treated between 1995 and 2018, focusing on the differences between those who underwent fundoplication (surgery to prevent reflux) and those who did not, finding significant differences in gestational age, body weight, and other factors.
- Key findings suggest that early delivery, low body weight, and long esophageal gap length are risk factors for requiring fundoplication, while prenatal diagnosis and polyhydramnios (
Introduction: Several studies have reported the treatment of pediatric appendicitis with single-incision laparoscopy-assisted appendectomy using a muscle hook without pneumoperitoneum to lift the abdominal wall. However, very few studies have investigated the advantages of this procedure. We examined the utility of this procedure in our department.
View Article and Find Full Text PDFBackground/aim: Chemotherapy dose adjustments in colorectal cancer are usually based on body surface area (BSA). The goal of this study was to investigate patients with nutritional disorder who developed early peripheral neuropathy due to inappropriate dose adjustment of oxaliplatin.
Patients And Methods: The study subjects were 88 patients with advanced or recurrent colorectal cancer who underwent chemotherapy with oxaliplatin.
In colorectal cancer perforation, selecting the appropriate surgical operation while considering the patient's life and radical treatment is important. We divided 15 patients who underwent surgical intervention at our department into 2 groups, namely, free and covering perforation groups, and conducted a retrospective analysis. In the comparison between the 2 groups (free vs covering), there were 11 vs 4 cases with similar morphology, 2 vs 0 cases of perioperative death, and 3 vs 0 cases of recurrence, respectively.
View Article and Find Full Text PDF[A Case of Cancerous Meningitis in Juvenile Onset Gastric Cancer].
Gan To Kagaku Ryoho
December 2018
A 30-year-old woman was diagnosed with advanced gastric cancer(MUL, Circ, Type 4, por1+2, T4a, N3a, M1[LYM, P1, CY1, H0], Stage Ⅳ)on delivery. Because of unresectable, she underwent chemotherapy(first-line: S-1 plus CDDP, secondline: PTX plus Rmab, and third-line: Nmab); approximately 10 months later, she started complaining of headache. We performed a close examination, because she also developed resistance to chemotherapy.
View Article and Find Full Text PDF