Publications by authors named "Kosuke Fuse"
Article Synopsis
- Tumor metastasis is a complex process and a leading cause of death, with previous research showing that the lack of apoptosis signal-regulating kinase 1 (ASK1) in mice reduces metastasis in lung models.
- The study found that ASK1 deficiency enhances the ability of natural killer (NK) cells to clear tumor cells from the bloodstream shortly after metastasis begins by upregulating immune response genes like interferon-gamma (IFNγ).
- The findings suggest that targeting ASK1 could boost NK cell activity and improve cancer immunotherapy, as ASK1 generally suppresses the anti-tumor immune response.
