Genetic architecture of cardiac dynamic flow volumes.

Cardiac blood flow is a critical determinant of human health. However, the definition of its genetic architecture is limited by the technical challenge of capturing dynamic flow volumes from cardiac imaging at scale. We present DeepFlow, a deep-learning system to extract cardiac flow and volumes from phase-contrast cardiac magnetic resonance imaging.

Low-density lipoprotein accumulation within the right coronary artery walls for physiological and hypertension conditions.

We demonstrate how low-density lipoproteins (LDL) are transported and accumulated through walls of the coronary artery. The result of modeling is a map of the LDL concentration on the patient specific vessel. It identifies places at high risk for plague growth.

Numerical analysis of the impact of flow rate, heart rate, vessel geometry, and degree of stenosis on coronary hemodynamic indices.

Background: The stenosis of the coronary arteries is usually caused by atherosclerosis. Hemodynamic significance of patient-specific coronary stenoses and the risk of its progression may be assessed by comparing the hemodynamic effects induced by flow disorders. The present study shows how stenosis degree and variable flow conditions in coronary artery affect the oscillating shear index, residence time index, pressure drop coefficient and fractional flow reserve.

Brownian ratchets: How stronger thermal noise can reduce diffusion.

We study diffusion properties of an inertial Brownian motor moving on a ratchet substrate, i.e., a periodic structure with broken reflection symmetry.

Low-density lipoprotein transport through an arterial wall under hypertension - A model with time and pressure dependent fraction of leaky junction consistent with experiments.

The influence of hypertension on low-density lipoproteins intake into the arterial wall is an important factor for understanding mechanisms of atherosclerosis. It has been experimentally observed that the increased pressure leads to the higher level of the LDL inside the wall. In this paper we attempt to construct a model of the LDL transport which reproduces quantitatively experimental outcomes.

Anisotropy of flow in stochastically generated porous media.

Models of porous media are often applied to relatively small systems, which leads not only to system-size-dependent results, but also to phenomena that would be absent in larger systems. Here we investigate one such finite-size effect: anisotropy of the permeability tensor. We show that a nonzero angle between the external body force and macroscopic flux vector exists in three-dimensional periodic models of sizes commonly used in computer simulations and propose a criterion, based on the ratio of the system size to the grain size, for this phenomenon to be relevant or negligible.

Two coupled Josephson junctions: dc voltage controlled by biharmonic current.

We study transport properties of two Josephson junctions coupled by an external shunt resistance. One of the junctions (say, the first) is driven by an unbiased ac current consisting of two harmonics. The device can rectify the ac current yielding a dc voltage across the first junction.

Negative mobility induced by colored thermal fluctuations.

Anomalous transport of non-Markovian thermal Brownian particle dynamics in spatially periodic symmetric systems that is driven by time-periodic symmetric driving and constant bias is investigated numerically. The Brownian dynamics is modeled by a generalized Langevin equation with exponentially correlated Gaussian thermal noise, obeying the fluctuation-dissipation theorem. We study the role of nonzero correlation time of thermal fluctuations for the occurrence of absolute negative (linear) mobility (ANM) near zero bias, negative-valued, nonlinear mobility (NNM), and negative differential mobility (NDM) at finite bias away from equilibrium.

Flow patterns and transport in Rayleigh surface acoustic wave streaming: combined finite element method and raytracing numerics versus experiments.

This work presents an approach for determining the streaming patterns that are generated by Rayleigh surface acoustic waves in arbitrary 3-D geometries by finite element method (FEM) simulations. An efficient raytracing algorithm is applied on the acoustic subproblem to avoid the unbearable memory demands and computational time of a conventional FEM acoustics simulation in 3-D. The acoustic streaming interaction is modeled by a body force term in the Stokes equation.

Transport characteristics of molecular motors.

Properties of transport of molecular motors are investigated. A simplified model based on the concept of Brownian ratchets is applied. We analyze a stochastic equation of motion by means of numerical methods.

Rectification in synthetic conical nanopores: a one-dimensional Poisson-Nernst-Planck model.

Ion transport in biological and synthetic nanochannels is characterized by phenomena such as ion current fluctuations and rectification. Recently, it has been demonstrated that nanofabricated synthetic pores can mimic transport properties of biological ion channels [P. Yu.

Microfluidic mixing via acoustically driven chaotic advection.

Mixing presents a notoriously difficult problem in small amounts of fluids. Herein, surface acoustic waves provide a convenient technique to generate time-dependent flow patterns. These flow patterns can be optimized in such a way that advected particles are mixed most efficiently in the fluid within a short time compared to the time pure diffusion would take.

Arrival time distribution for a driven system containing quenched dichotomous disorder.

We study the arrival time distribution of overdamped particles driven by a constant force in a piecewise linear random potential which generates the dichotomous random force. Our approach is based on the path integral representation of the probability density of the arrival time. We explicitly calculate the path integral for a special case of dichotomous disorder and use the corresponding characteristic function to derive prominent properties of the arrival time probability density.

Analytically solvable model of a driven system with quenched dichotomous disorder.

We perform a time-dependent study of the driven dynamics of overdamped particles that are placed in a one-dimensional, piecewise linear random potential. This setup of spatially quenched disorder then exerts a dichotomous varying random force on the particles. We derive the path integral representation of the resulting probability density function for the position of the particles and transform this quantity of interest into the form of a Fourier integral.

Absolute negative mobility induced by thermal equilibrium fluctuations.

A novel transport phenomenon is identified that is induced by inertial Brownian particles which move in simple one-dimensional, symmetric periodic potentials under the influence of both a time periodic and a constant, biasing driving force. Within tailored parameter regimes, thermal equilibrium fluctuations induce the phenomenon of absolute negative mobility (ANM), which means that the particle noisily moves backwards against a small constant bias. When no thermal fluctuations act, the transport vanishes identically in these tailored regimes.

Neuron firing in driven nonlinear integrate-and-fire models.

Statistical properties of neuron firing are studied in the framework of a nonlinear leaky integrate-and-fire model that is driven by a slow periodic subthreshold signal. The firing events are characterized by first passage time densities. The experimentally better accessible interspike interval density generally depends on the sojourn times in a refractory state of the neuron.

Quantum diffusion in biased washboard potentials: strong friction limit.

Diffusive transport properties of a quantum Brownian particle moving in a tilted spatially periodic potential and strongly interacting with a thermostat are explored. Apart from the average stationary velocity, we foremost investigate the diffusive behavior by evaluating the effective diffusion coefficient together with the corresponding Peclet number. Corrections due to quantum effects, such as quantum tunneling and quantum fluctuations, are shown to substantially enhance the effectiveness of diffusive transport if only the thermostat temperature resides within an appropriate interval of intermediate values.

Chiral separation in microflows.

Molecules that only differ by their chirality, so-called enantiomers, often possess different properties with respect to their biological function. Therefore, the separation of enantiomers presents a prominent challenge in molecular biology and has long been a main pursuit of organic chemistry. We suggest a new separation technique for chiral molecules that is based on the transport properties in a microfluidic flow with spatially variable vorticity.

Optimal strategy for controlling transport in inertial Brownian motors.

In order to optimize the directed motion of an inertial Brownian motor, we identify the operating conditions that both maximize the motor current and minimize its dispersion. Extensive numerical simulation of an inertial rocked ratchet displays that two quantifiers, namely the energetic efficiency and the Péclet number (or equivalently the Fano factor), suffice to determine the regimes of optimal transport. The effective diffusion of this rocked inertial Brownian motor can be expressed as a generalized fluctuation theorem of the Green-Kubo type.

Anticipated synchronization in coupled inertial ratchets with time-delayed feedback: a numerical study.

We investigate anticipated synchronization between two periodically driven deterministic, dissipative inertial ratchets that are able to exhibit directed transport with a finite velocity. The two ratchets interact through a unidirectional delay coupling, one is acting as a master system while the other one represents the slave system. Each of the two dissipative deterministic ratchets is driven externally by a common periodic force.

Effects of pre-analytical variables on the anti-activated factor X chromogenic assay when monitoring unfractionated heparin and low molecular weight heparin anticoagulation.

The purpose of this study was to determine whether the anti-activated factor X (anti-FXa) assay is less affected by pre-analytical variables in monitoring patients on unfractionated heparin (UFH) and low molecular weight heparin (LMWH) than the activated partial thromboplastin time (aPTT). Forty-six subjects receiving either enoxaparin (LMWH) or UFH were randomly selected. Each study subject had six vacutainer tubes (3.

Brownian motors: current fluctuations and rectification efficiency.

With this work, we investigate an often neglected aspect of Brownian motor transport, namely, the role of fluctuations of the noise-induced current and its consequences for the efficiency of rectifying noise. In doing so, we consider a Brownian inertial motor that is driven by an unbiased monochromatic, time-periodic force and thermal noise. Typically, we find that the asymptotic, time-, and noise-averaged transport velocities are small, possessing rather broad velocity fluctuations.

Flow profiling of a surface-acoustic-wave nanopump.

The flow profile in a capillary gap and the pumping efficiency of an acoustic micropump employing surface acoustic waves is investigated both experimentally and theoretically. Ultrasonic surface waves on a piezoelectric substrate strongly couple to a thin liquid layer and generate a quadrupolar streaming pattern within the fluid. We use fluorescence correlation spectroscopy and fluorescence microscopy as complementary tools to investigate the resulting flow profile.

Consistent description of quantum Brownian motors operating at strong friction.

A quantum Smoluchowski equation is put forward that consistently describes thermal quantum states. In particular, it notably does not induce a violation of the second law of thermodynamics. This so modified kinetic equation is applied to study analytically directed quantum transport at strong friction in arbitrarily shaped ratchet potentials that are driven by nonthermal two-state noise.

Interventional procedures in acute myocardial infarction.

Acute myocardial infarction (AMI) is a leading cause of death in the western world. Primary percutaneous intervention (PCI) has emerged as an effective therapy that may improve survival and decrease morbidity in patients with AMI. Our article discusses the advantages of PCI over thrombolytic therapy and reviews currently available techniques.