Bronchodilating effects of a new beclometasone dipropionate plus formoterol fumarate formulation via pressurized metered-dose inhaler in asthmatic children: a double-blind, randomized, cross-over clinical study.

A new pediatric fixed combination of beclometasone dipropionate (BDP) 50 μg and formoterol fumarate (FF) 6 μg via pressurized metered-dose inhaler (pMDI) (CHF1535, Chiesi, Italy) was investigated. In a double-blind, randomized, placebo-controlled, cross-over study, a single CHF1535 administration using AeroChamber Plus™ spacer device (2 actuations, total dose BDP 100 μg/FF 12 μg) was compared to the same pMDI free combination in 56 asthmatic children aged ≥ 5 and < 12 years. Primary efficacy variable was forced expiratory volume during the first second (FEV) area under the curve corrected by time over 12 h following morning dose (AUC).

[Evaluation of the efficacy of a plant adaptogen (spirulina) in the pathognic therapy of primary tuberculosis in children].

The use of spirulina and its efficiency have been studied in a comparative aspect as a systemic biocorrector, in a combined treatment of tuberculosis in 26 children. It has been ascertained that application of spirulina as a pathogenetic means of remediation permits shortening the intoxication syndrome regression time, reducing the frequency of adverse reactions in administering antituberculous preparations.

[Reasons for hospital readmission of infants and preschool children with tuberculosis].

As high as 12.4% of children suffering from tuberculosis are readmitted, rural children are more frequently readmitted (18.0 versus 7.

[Improving the activities of tuberculosis sanatoria for children and adolescents].

The paper deals with the examination of the state of health of children treated at tuberculosis sanatoria of republican and local importance. At present the tuberculosis sanatoria for children are not considered any more to be strickly uniprofile. The emphasis of their activities is aimed at conducting controlled chemotherapeutic prevention measures among children with small attenuating forms of tuberculosis as well as among those who belong to high risk groups in relation to tuberculosis including concurrent bronchopulmonary diseases of nonspecific etiology.

[Use of computerized tomography in the differential diagnosis of spherical and cavitary formations in the lungs of children and adolescents].

Computed tomography (CT) of the chest organs was used in a comprehensive examination of 19 children and adolescents with spherical and cavitary formations in their lungs and mediastinum. Comparative analysis of the results obtained by means of routine X-ray examination and CT of the chest organs of the children and adolescents with spherical and cavitary formations in their lungs revealed that CT greatly improved their differential diagnosis. CT provides valuable additional data and is an optimum X-ray method for differential diagnosis of spherical and cavitary formations in children and adolescents.

[Comparative estimation of tuberculin reactions using a ruler and thermographic film followed by histological examination of the papule in guinea pigs].

The time course of tuberculin reactions during isoniazid treatment was studied on 10 guinea pigs with experimental tuberculosis. Linear, temperature and histological characteristics of papules were investigated. Thermographic estimation of papules was performed with cholesteric liquid crystal films.

[The systemic immunity of schoolchildren from foci of tuberculosis infection].

Seventy-eight tuberculin-positive schoolchildren at the age of 7 to 15 years from tuberculosis foci living in special institutions of the sanatorium type were subjected to immunological examination. The control group included 22 noninfected children of the same age. Persons with lower counts of T-lymphocytes and their decreased functional activity, unbalance in their subpopulation composition and positive immunospecific responses to tuberculin predominated among the schoolchildren subjected to the examination.