[The interrelationship of the arterial and venous sections of the systemic vascular bed under the action of verapamil and propranolol].

Electromagnetic flowmetry and analogue computer techniques were used in the experiments on 12 anesthesized cats which indicated that verapamil increased cardiac output (CO) (due to lower afterload) and venous return (VR), distributed CO, by improving brain blood supply. The latter was due to more marked decrease in the vascular resistance of the brachiocephalic artery than that in the descending thoracic aorta. Propranolol diminished CO due to higher afterload, lower VR and cardiac pump function.

[Effect of nifedipine and verapamil on the interaction of arterial and venous systemic hemodynamics].

Electromagnetic flowmetry and analogue computers were used to evaluate changes in great venous and arterial blood flow and resistance alterations in the vessels after nifedipine and verapamil in experiments with 12 anesthesized cats. The agents were demonstrated to increase cardiac output due to lower afterload and venous return, to redistribute cardiac output towards greater brain blood supply. The latter was caused by a more marked decrease in vascular resistance in the brachiocephalic arterial tree than in the descending thoracic artery.

[The effect of verapamil on the course of stenocardia of effort, on the blood serum lipid level and on the basic indices of carbohydrate metabolism during the long-term use of the preparation].

The therapeutical efficiency of verapamil given for 3 months was studied in 36 patients with stable exercise-induced angina by multistep gradually increasing bicycle ergometry exercise test. The effects of the agent on serum lipid levels were evaluated in 30 cases. The therapeutical effect was achieved in 24 patients; verapamil caused a pronounced increase in physical working capacity just during the acute drug test in all cases and showing growing effects within a month of treatment.

[Adhesive activity of blood platelets in patients with stable or unstable angina pectoris and acute myocardial infarct].

Platelet adhesive activity was assayed in patients with stable angina (SA) or unstable angina (UA) and acute myocardial infarction (AMI). With scanning electron microscopy, platelet adhesions to Type IV collagen (C-IV) and plastic material, which had been stimulated by low-dose ADP, epinephrine and U-46 619, a stable thromboxane A2 analogue (agonist-induced adhesion) were determined. As compared with the control group, patients with SA or UA, showed significantly higher adhesion of platelets to the collagen substrate, whereas UA patients alone displayed a significantly increased agonist-induced adhesion when epinephrine was employed as an agonist.

[Changes in central hemodynamics and gas exchange after a single and scheduled administration of obsidan in patients with exertion-induced stenocardia and various types of blood circulation].

Sixty-two patients with angina of effort and different circulation types were investigated to assess the pattern of changes in hemodynamics and gas exchange following an acute obsidan test and a course of obsidan treatment. A relationship was demonstrated between the effect of obsidan on central hemodynamics and gas exchange, on the one hand, and the baseline circulatory type, on the other. In patients with hyper- and eukinetic circulation, the drug increased the maximum oxygen uptake and total performance volume in the presence of a variety of hemodynamic changes; such as the negative inotropic and chronotropic effects in the hyperkinetic-type patients, and the negative chronotropic effect in the eukinetic-type ones.

[Comparative anti-angina effectiveness of metoprolol and propranolol].

A study of comparative antianginal efficiency of metoprolol (betaloc) and propranolol (anaprilin) in 30 patients with angina of effort, receiving single doses and courses of the treatment, demonstrated similar efficiency of the two drugs in 63.3% of the patients. In 30%, antianginal effect of metoprolol was superior to that of propranolol.

[Differences in the effects of corinfar and nitroglycerin on coronary blood flow and myocardial function].

In acute experiments with 20 isolated cat hearts, corinfar (0.1, 1, and 10 micrograms) and nitroglycerin (1, 10, and 100 micrograms) and their combination were tested for their effects on cardiac vessels and performance. Corinfar and nitroglycerin were found to exert a dose-dependent coronary dilating effect; however, more pronounced and prolonged action was shown by corinfar.

[Effect of anaprilin on the clinical course of stenocardia and the carbohydrate metabolic indices of ischemic heart disease patients in relation to the nature of their glucose tolerance].

Fourteen-day anaprilin treatment of coronary patients with varying glucose tolerance has demonstrated that the drug's therapeutic efficiency was greater in patients with normal glucose tolerance. Anaprilin caused a moderate drop in baseline glucose level and considerably limited the degree of hyperglycemia in response to the glucose tolerance test in coronary patients with abnormally low glucose tolerance. Insulin content was virtually unaffected by the drug, irrespective of the type of glucose tolerance.

[Effect of corinfar on the course of angina pectoris and indices of carbohydrate metabolism in relation to the type of glucose tolerance].

Nifedipine influence on a clinical course of angina pectoris, some indices of hemodynamics, glucose and insulin was studied in 39 male patients suffering from coronary heart disease (CHD) with different glucose tolerance. In CHD patients with normal glucose tolerance (NGT) nifedipine therapy did not cause any considerable changes in the blood levels of glucose and insulin whereas in patients with lowered glucose tolerance (LGT) a hypoglycemic effect of the drug and an increase in the level of insulin were noted during therapy. An increase in physical exercise tolerance, a decrease in the frequency of anginal attacks, and a decrease in the number of nitroglycerin tablets administered by CHD patients with LGT per week were significant.

[Macro- and microhemodynamics and transcapillary fluid exchange in skeletal muscle and the intestines after intra-arterial injection of obsidan and corinfar].

In the cat autoperfused and hemodynamically isolated m. gastrocnemius and small intestine, i.a.

[Correlation between the therapeutic effectiveness of corinfar and its dose in patients with exercise-induced stenocardia].

A study of the antianginal efficacy of corinfar therapy by courses at daily doses of 30 and 60 mg (14 days) was carried out in 20 patients (males) with typical angina pectoris. Individual variability of response to the studied drug doses was noted. A high increment of tolerance to physical exercise on the bicycle ergometer was noted in the 1st group of patients using even small doses (30mg), in the 2nd group the antianginal effect was observed after increasing the dose up to 60 mg and in the 3rd group no effect was observed with any of the doses.

[Various aspects of the effects of beta adrenergic receptor blockaders, stimulants and calcium antagonists on the cardiovascular system].

Experiments with isolated animal hearts showed that intracoronarily injected propranolol (beta-adrenoblocker) and nonachlasine (beta-adrenostimulator) lead to coronary dilatation changing into coronary constriction. Unlike propranolol, nonachlasine reduced the venous bed capacity. The use of nonachlasine resulted in primary reduction and consequent increase of myocardial contractility, propranolol leading to negative inotropic effect.

[Indicators of spiroveloergometry and the sympathetic-adrenal system in patients with exertion-induced angina pectoris with different types of circulation].

The response of the cardiorespiratory and sympathoadrenal (SA) systems to exercise in coronary heart disease patients was found to depend on the hemodynamic type of circulation and the initial activity of the SA system. In patients with the hyperkinetic type of the circulation showing a high initial activity of the SA system and the absence of its response to exercise, the authors observed an increased consumption of oxygen both at rest and during mild exercise which indicated that oxygen expenditure in these patients was ineffective, and subsequently led to a reduction in their capacity to do physical work. Patients with the hypokinetic circulation type and an initially low activity of the SA system exhibited a considerable elevation in the activity of the hormonal component of the SA system during exercise.

[Changes in the physical load tolerance of stenocardia patients taking obzidan, korinfar and izoptin separately and together].

Changes in exercise tolerance under the impact of obsidan, corinfar, isoptin and their combinations were studied in 12 angina patients with the help of bicycle ergometry. The most marked increase in exercise tolerance following the use of a single drug was observed with obsidan (85.1 +/- 35.

[Functional state of the myocardium during stenocardia induced by isoproterenol].

Hemodynamic changes in healthy subjects versus patients with chronic coronary heart disease are compared. In cases of isoproterenol caused tachycardia, the patients developing angina showed a less prominent beneficial inotropic effect as compared with healthy subjects and angina-free patients. The initiation of drug infusion led to a marked increase in the rheographic index of myocardial contractility; however, already in the initial stages of ST segment depression, this parameter was characterized by a reversed time-course which progressed with the increasing electrocardiographic signs of myocardial ischemia.

[Effect of obzidan on the indices of gas exchange and the sympathetic-adrenal system in ischemic heart disease patients with different types of circulation].

The relationship between the effect of propranolol treatment on oxygen consumption during exercise and the activity of the sympathoadrenal system (SAS) and the initial hemodynamic circulatory type was established in patients with coronary heart disease (CHD). In patients with the hyper- and eukinetic circulatory types, propranolol caused an increase in the maximal oxygen consumption (MOC), pointing to the improvement of the functional possibilities of the cardiovascular system during exercise, with this improvement being more marked in patients with the hyperkinetic type. This effect of propranolol in the latter group patients was coupled with a reduction in the transmitter activity of the SAS.