Publications by authors named "Kostiantyn Shvydenko"
Article Synopsis
- Researchers used DFT and ab initio calculations to show that noncyclic formamidines can convert to isomeric aminocarbenes with relatively low energy requirements.
- They synthesized silylformamidine, which was confirmed to be an extremely reactive nucleophilic carbene through experimental studies.
- This nucleophilic carbene can react with a variety of compounds like acetylenes and functional groups, and it has potential for bulk preparation and storage for later use.
A general approach to a new generation of spirocyclic molecules - oxa-spirocycles - was developed. The key synthetic step was iodocyclization. More than 150 oxa-spirocyclic compounds were prepared.
View Article and Find Full Text PDFCancer still remains a major public health concern around the world and the search for new potential antitumor molecules is essential for fighting the disease. This study evaluated the anticancer and immunomodulatory potential of the newly synthetized ellipticine derivate: sodium bromo-5,11-dimethyl-6H-pyrido[4,3-b]carbazole-7-sulfonate (Br-Ell-SONa). It was prepared by the chlorosulfonation of 9-bromoellipticine.
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