Publications by authors named "Kostas Lafazanis"
Article Synopsis
- The study aims to create a patient-derived orthotopic xenograft (PDOX) model for pancreatic ductal adenocarcinoma (PDAC) to better mimic the human pancreas environment for discovering new biomarkers and treatments.
- The researchers used PDAC tissue samples from 35 patients and tested two types of mice, finding better success in tumor growth with NSG mice due to their enhanced immunosuppression.
- This PDOX model is poised to significantly advance preclinical research on PDAC by closely replicating the patient's tumor microenvironment.
J Inorg Biochem
April 2013
Article Synopsis
- Interaction of ZnCl2 with quinolone antibiotics and N,N'-donor ligands forms 1:1 and 1:2 complexes with specific structural coordination to the zinc ion.
- Crystal structures of some complexes have been determined, showing strong binding affinity to serum albumin and significant interaction with calf-thymus DNA, indicating a competitive binding mode.
- The complexes demonstrate notable antimicrobial activity against five different types of microorganisms, alongside their ability to affect DNA structure and stability.
