Publications by authors named "Kostantinos Manolas"
Bevacizumab, capecitabine, amifostine, and preoperative hypofractionated accelerated radiotherapy (HypoArc) for rectal cancer: a Phase II study.
Michael I Koukourakis Alexandra Giatromanolaki Pelagia Tsoutsou Nikolaos Lyratzopoulos Michael Pitiakoudis Kostantinos Manolas
Int J Radiat Oncol Biol Phys
June 2011
Purpose: Bevacizumab has established therapeutic activity in patients with metastatic colorectal cancer, and anti-vascular endothelial growth factor therapy enhances the activity of radiotherapy in experimental models. We assessed the feasibility and efficacy of preoperative radiochemotherapy combined with bevacizumab in patients with rectal cancer.
Methods And Materials: Nineteen patients with radiologic T3 and/or N+ rectal carcinoma were treated with preoperative conformal hypofractionated accelerated radiotherapy (3.