Myocilin variations and familial glaucoma in Taxiarchis, a small Greek village.

Purpose: To initiate a prospective study of glaucoma in a Greek village reported over 30 years ago to have several large families with primary open-angle glaucoma (POAG).

Methods: A random group of 126 villagers from Taxiarchis, Greece was examined in the village community center. The detailed evaluation included ophthalmic and general history, measurement of blood pressure, intraocular pressure (IOP), and central corneal thickness (CCT) as well as evaluation of the optic nerve status.

24-Hour control with a latanoprost-timolol fixed combination vs timolol alone.

Objective: To evaluate 24-hour intraocular pressure (IOP) control with an evening-dosed latanoprost-timolol maleate fixed combination vs timolol alone in patients with primary open-angle glaucoma.

Methods: After a medicine-free period, qualified patients were randomized to either placebo dosed in the morning with a latanoprost-timolol fixed combination dosed in the evening or timolol alone dosed twice daily for 8 weeks. Patients were then switched to the opposite treatment for 8 weeks.

24-hour intraocular pressure control obtained with evening- versus morning-dosed travoprost in primary open-angle glaucoma.

Purpose: To evaluate the quality of 24-hour intraocular pressure (IOP) control between morning- and evening-dosed travoprost in primary open-angle glaucoma patients.

Design: Prospective, crossover, double-masked comparison.

Methods: After a 6-week medicine-free period, 33 patients were randomized to receive travoprost dosed in the morning or evening.