Publications by authors named "Kostandinos C Tsoulfas"
Long-term efficacy of high-frequency (10 kHz) spinal cord stimulation for the treatment of painful diabetic neuropathy: 24-Month results of a randomized controlled trial.
Diabetes Res Clin Pract
September 2023
Aims: To evaluate the long-term efficacy of high-frequency (10 kHz) spinal cord stimulation (SCS) for treating refractory painful diabetic neuropathy (PDN).
Methods: The SENZA-PDN study was a prospective, multicenter, randomized controlled trial that compared conventional medical management (CMM) alone with 10 kHz SCS plus CMM (10 kHz SCS+CMM) in 216 patients with refractory PDN. After 6 months, participants with insufficient pain relief could cross over to the other treatment.
High-Frequency 10-kHz Spinal Cord Stimulation Improves Health-Related Quality of Life in Patients With Refractory Painful Diabetic Neuropathy: 12-Month Results From a Randomized Controlled Trial.
Mayo Clin Proc Innov Qual Outcomes
August 2022
Article Synopsis
- A study evaluated the effectiveness of 10-kHz spinal cord stimulation (SCS) combined with conventional medical management (CMM) in patients with chronic, painful diabetic neuropathy who did not respond to standard pain treatments.
- Participants who received 10-kHz SCS reported significant pain relief (average 74.3% reduction) and improved quality of life (HRQoL) compared to those receiving only CMM, with 92% expressing satisfaction with the treatment.
- The results support the use of 10-kHz SCS as a viable option for individuals with poorly managed diabetic neuropathy pain, showing durable benefits over a 12-month period.
Durability of High-Frequency 10-kHz Spinal Cord Stimulation for Patients With Painful Diabetic Neuropathy Refractory to Conventional Treatments: 12-Month Results From a Randomized Controlled Trial.
Diabetes Care
January 2022
Importance: Many patients with diabetic peripheral neuropathy experience chronic pain and inadequate relief despite best available medical treatments.
Objective: To determine whether 10-kHz spinal cord stimulation (SCS) improves outcomes for patients with refractory painful diabetic neuropathy (PDN).
Design, Setting, And Participants: The prospective, multicenter, open-label SENZA-PDN randomized clinical trial compared conventional medical management (CMM) with 10-kHz SCS plus CMM.