Validation of capture reactions cross sections in Cf(s.f.) neutron field.

We have investigated following capture reactions: Au(n,g)Au, Cu(n,g)Cu, Sc(n,g)Sc, Ta(n,g)Ta, Ce(n,g)Ce, La(n,g)La, Yb(n,g)Yb, Mn(n,g)Mn, and Pr(n,g)Pr in a standard Cf(s.f.) neutron field.

Technology and provenience of the oldest pottery in the northern Pannonian Basin indicates its affiliation to hunter-gatherers.

Consensus holds that pottery technology came to Central Europe from the Northern Balkans with independent pottery traditions existing concurrently in Eastern Europe. An unusual grass-tempered pottery dating back to around 5800 cal BC found in lake sediments at Santovka, Slovakia, predated the earliest known Neolithic pottery in the region (~ 5500 cal BC), suggesting unexplored narratives of pottery introduction. Analyses of the pottery's technology, origin, and grass temper shedding light on ceramic traditions' spread can unveil mobility patterns and community lifestyles.

A Taxonomic Revision of the Genus Dejean, 1821 (Coleoptera, Curculionidae), with Descriptions of 13 New Species.

The genus Dejean, 1821 is herein revised for the first time. Based on adult morphological characteristics, 18 species are recognized as valid. Thirteen species, all distributed in the Eastern Palaearctis or Oriental region, are described as new: sp.

Measurement of spectral averaged cross sections of capture reactions in the LR-0 reference neutron field.

Nuclear data evaluations are periodically updated to render state of the art of knowledge, and the independent validation experiments are still of interest of the community. Current work describes validation of selected capture reactions used for monitoring of thermal neutrons in mixed fields, as well as reactions responsible for activation of components exposed to neutron flux. The validation was performed also for reaction Cr (n,γ), which is very important reaction directly affecting criticality safety, because chromium is essential component of stainless steel used as structural component of the core baffle closely adjoining to nuclear fuel.

The spectrum-averaged cross section investigation of Sn(n,n')Sn and Zn(n,p)Cu reactions.

The spectrum averaged cross sections (SACS) in standard neutron field, e.g. Cf(s.

Long-term treatment with rilzabrutinib in patients with immune thrombocytopenia.

Immune thrombocytopenia (ITP) is an autoimmune disease associated with autoantibody-mediated platelet destruction and impaired platelet production, resulting in thrombocytopenia and a predisposition to bleeding. The ongoing, global phase 1/2 study showed that rilzabrutinib, a Bruton tyrosine kinase inhibitor specifically developed to treat autoimmune disorders, could be an efficacious and well-tolerated treatment for ITP. Clinical activity, durability of response, and safety were evaluated in 16 responding patients who continued rilzabrutinib 400 mg twice daily in the long-term extension (LTE) study.

Experimental validation of Na( γ, n)Na cross section.

Photonuclear reactions are gaining importance due to their influence on the shielding and activation of components of widely spread accelerators. Therefore, there is a need for accurate data describing photonuclear reactions. The MT25 microtron operated at NPI was used for validation of cross section in the bremsstrahlung.

Lymphocyte subpopulations: a potential predictor of a response in patients with immune thrombocytopenia.

Objectives: Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder caused by increased platelet destruction and altered production. Despite the well-described pathophysiological background of immune dysregulation, current treatment guidelines consist of monotherapy with different drugs, with no tool to predict which patient is more suitable for each therapeutic modality.

Methods: In our study, we attempted to determine differences in the immune setting, comparing the patients' responses to administered therapy.

A TAXONOMIC REVISION OF THE AFROTROPICAL SPECIES OF THE WEEVIL GENUS CIONUS (COLEOPTERA: CURCULIONIDAE).

The Afrotropical species of the genus Cionus Clairville, 1798 are revised and 52 species are recognized as valid. Thirty-one species are described as new to the science: twenty-five from the continental subregions (C. concavifrons sp.

A Taxonomic Revision of the Genus (Coleoptera, Curculionidae) from the Oriental Region.

Oriental species of the genus are herein revised for the first time. Eight species are recognized as distinct based on morphological characters of adults. One species is described as new: sp.

Characterization of the secondary neutron field inside a cyclotron for production of radiopharmaceuticals.

During production of radiopharmaceuticals, the radiation situation in cyclotron pit is an important parameter, which is being monitored to ensure fulfilment of the limits and conditions of safe operation. The neutron flux in the structural components of the accelerator is also an important parameter, because the secondary neutrons are responsible for activation of cyclotron structural components and may even affect structural changes in it. This paper aims to characterize the neutron field in inner positions of medical accelerator IBA 18/9 by activation detectors and by means of scintillation spectrometry.

MEASUREMENT OF PROMPT GAMMAS OF INELASTIC SCATTERING IN D2O SPHERE USING AMBE SOURCE.

The inelastic neutron scattering is often followed by the emission of gamma photon. As the prompt gammas have a discrete level character they can be used for the identification of nuclides. Because of this fact, a good knowledge of photon production from inelastic scattering is important.

Spectrum averaged cross section measurements of lutetium using standard Cf neutron source.

The spectrum averaged cross section (SACS) in a standard neutron field is a preferable tool for cross section validation. The presented work uses only neutron standard, i.e.

Rilzabrutinib, an Oral BTK Inhibitor, in Immune Thrombocytopenia.

Background: Rilzabrutinib, an oral, reversible covalent inhibitor of Bruton's tyrosine kinase, may increase platelet counts in patients with immune thrombocytopenia by means of dual mechanisms of action: decreased macrophage (Fcγ receptor)-mediated platelet destruction and reduced production of pathogenic autoantibodies.

Methods: In an international, adaptive, open-label, dose-finding, phase 1-2 clinical trial, we evaluated rilzabrutinib therapy in previously treated patients with immune thrombocytopenia. We used intrapatient dose escalation of oral rilzabrutinib over a period of 24 weeks; the lowest starting dose was 200 mg once daily, with higher starting doses of 400 mg once daily, 300 mg twice daily, and 400 mg twice daily.

Mitochondrial Respiration of Platelets: Comparison of Isolation Methods.

Multiple non-aggregatory functions of human platelets (PLT) are widely acknowledged, yet their functional examination is limited mainly due to a lack of standardized isolation and analytic methods. Platelet apheresis (PA) is an established clinical method for PLT isolation aiming at the treatment of bleeding diathesis in severe thrombocytopenia. On the other hand, density gradient centrifugation (DC) is an isolation method applied in research for the analysis of the mitochondrial metabolic profile of oxidative phosphorylation (OXPHOS) in PLT obtained from small samples of human blood.

Sacrospinous hysteropexy - an alternative in primary surgical treatment of apical compartment prolapse.

Objective: To present a surgical treatment of pelvic organ prolapse and its outcomes according to the literature.

Methods: PubMed database search.

Conclusion: Pelvic organ prolapse is a common diagnosis with prevalence around 40% of female population.

Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications.

Toxic epidermal necrolysis (TEN) is a rare disease, which predominantly manifests as damage to the skin and mucosa. Antibiotics count among the most common triggers of this hypersensitive reaction. Patients with TEN are highly susceptible to infectious complications due to the loss of protective barriers and immunosuppressant therapy.

Testing of various neutron filters in reference neutron field in LR-0 reactor for nuclear data validation and verification.

Neutron activation analysis is the reference method used for offline determination of the neutron flux density in defined positions. It can be used in the nuclear energy industry-as well as in medical- or space applications. For accurate neutron flux evaluation, well-known and reliable cross sections are needed.

Measurement of very high threshold reactions using Cf source.

Only neutron spectrum standard is Cf spontaneous fission neutron spectrum. However, the high energy tail of this spectrum is loaded with high uncertainty. To reduce this uncertainty, it is crucial to use validated cross sections with low uncertainty.

Constraining high energy tail of U(n,f) prompt fission neutron spectrum.

There is a lack of reliable experiments aiming at the prompt fission neutron spectrum of U for energies higher than 10 MeV. The presented experiment performed at the LVR-15 light water reactor aimed at the measurement of very high threshold reactions spectral averaged cross sections such as Mn (n,2n)Mn, Au (n,2n)Au, Au (n,3n)Au, Bi(n,3n)Bi, Bi(n,4n)Bi. Bi(n,3n)Bi and Bi(n,4n)Bi reactions were measured for the first time.

Prediction of long-term prognosis of age-related macular degeneration treated by hemorheologic therapy using baseline laboratory indicators - Experimental-clinical model.

Unlabelled: BACKGROUND + OBJECTIVE:Age-related macular degeneration (AMD) is the most common cause of practical blindness in people over 60 years of age in industrialised countries. We formulated a hypothesis that a group of initial laboratory parameters would be suitable for prediction of prognosis of AMD, allowing for individual modifications in treatment intensity.

Patients And Methods: 66 patients with dry form of AMD were treated using rheohaemapheresis with an individual follow-up period of more than 5 years.

Ph myeloproliferative neoplasms and the related risk factors for stroke occurrence: Results from a registry of patients treated with Anagrelide.

Arterial thrombosis is a common complication in patients with Ph myeloproliferative neoplasms (MPN). We searched for the risk factors of stroke in MPN patients from anagrelide registry. We analyzed the potential risk factors triggering a stroke/TIA event in 249 MPN patients with previous stroke (n = 168) or Transient Ischemic Attack (TIA) (n = 140), and in 1,193 MPN control subjects (without clinical history of thrombosis).

INVESTIGATION OF NUCLEAR EMULSIONS IN TERMS OF NEUTRON DOSIMETRY.

Neutron detection using nuclear emulsions can offer an alternative in personal dosimetry. The production of emulsions and their quality have to be well controlled with respect to their application in dosimetry. Nuclear emulsions consist mainly of gelatin and silver halide.

Heparin-induced thrombocytopenia treated with fondaparinux: single center experience.

Background: Heparin-induced thrombocytopenia (HIT) is the most frequent drug-induced, immune-mediated thrombocytopenia. It is associated with significant morbidity and mortality. Anticoagulation with heparin must be stopped immediately and replaced by some suggested alternative - lepirudin, danaparoid or argatroban.