Correction: Belyaeva et al. Tuberculosis and Autoimmunity. 2022, , 298-318.

The authors would like to make the following correction to the published paper [...

Tuberculosis and Autoimmunity.

Tuberculosis remains a common and dangerous chronic bacterial infection worldwide. It is long-established that pathogenesis of many autoimmune diseases is mainly promoted by inadequate immune responses to bacterial agents, among them Mycobacterium tuberculosis. Tuberculosis is a multifaceted process having many different outcomes and complications.

Anti-tumoural activity of the G-quadruplex ligand pyridostatin against BRCA1/2-deficient tumours.

The cells with compromised BRCA1 or BRCA2 (BRCA1/2) function accumulate stalled replication forks, which leads to replication-associated DNA damage and genomic instability, a signature of BRCA1/2-mutated tumours. Targeted therapies against BRCA1/2-mutated tumours exploit this vulnerability by introducing additional DNA lesions. Because homologous recombination (HR) repair is abrogated in the absence of BRCA1 or BRCA2, these lesions are specifically lethal to tumour cells, but not to the healthy tissue.

Poly(ADP-ribosyl)ation and DNA repair synthesis in the extracts of naked mole rat, mouse, and human cells.

DNA repair capacity in cells of naked mole rat (Hgl), a species known for its longevity and resistance to cancer, is still poorly characterized. Here, using the whole-cell extracts (WCEs) of Hgl, mouse and human cells, we studied the interrelation between DNA synthesis on the substrates of base excision repair and the activity of poly(ADP-ribose) polymerases (PARPs) responsible for the transfer of the ADP-ribose moieties onto different targets. The level of PAR synthesis was more than ten-fold higher in human WCE as compared to rodent WCEs, while the efficiency of DNA synthesis was comparable.

Role of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in DNA Repair.

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is widely known as a glycolytic enzyme. Nevertheless, various functions of GAPDH have been found that are unrelated to glycolysis. Some of these functions presume interaction of GAPDH with DNA, but the mechanism of its translocation to the nucleus is not fully understood.

Ku antigen displays the AP lyase activity on a certain type of duplex DNA.

In the search for proteins reactive to apurinic/apyrimidinic (AP) sites, it has been earlier found that proteins of human cell extracts formed the Schiff-base-dependent covalent adduct with an apparent molecular mass of 100kDa with a partial DNA duplex containing an AP site and 5'- and 3'-protruding ends (DDE-AP DNA). The adduct of such electrophoretic mobility was characteristic of only DDE-AP DNA (Ilina et al., Biochem.

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) interacts with apurinic/apyrimidinic sites in DNA.

Apurinic/apyrimidinic (AP) sites are some of the most frequent DNA damages and the key intermediates of base excision repair. Certain proteins can interact with the deoxyribose of the AP site to form a Schiff base, which can be stabilized by NaBH4 treatment. Several types of DNA containing the AP site were used to trap proteins in human cell extracts by this method.

[The role of Ku antigen in the repair of apurinic/apyrimidinic sites in DNA].

Apurinic/apyrimidinic (AP) sites are some of the most frequent lesions in genomic DNA. It is widely accepted that, irrespective of their origin, AP sites are further processed by the base excision repair (BER) machinery, being the central intermediate of this process. Under special conditions, proteins, which recognize AP sites, are able to form covalent adducts with DNA.

Single right coronary artery with hypoplastic left coronary artery represented by only descending septal branch from the right sinus of Valsalva.

A case is presented with combined anomalies of coronary arteries: single dominant right coronary artery, ectopic origin of hypoplastic left coronary artery from the right sinus of Valsalva, anomalous interseptal course of the latter artery, absence of typical left descending and circumflex arteries from the left coronary artery and presence of myocardial bridging.

Sleep characteristics, chronotype and winter depression in 10-20-year-olds in northern European Russia.

The purpose of this work was to examine the relationships between geographical coordinates and the prevalence of winter depression (SADW ), and to compare the sleep characteristics and chronotype of youths with and without SADW . We conducted a cross-sectional study of self-reported sleep characteristics, chronotype and winter depression in northern European Russia. Two questionnaires, the Munich Chronotype Questionnaire (MCTQ) and the Seasonal Pattern Assessment Questionnaire (SPAQ), were administered to a total of 3435 adolescents aged 10-20 years (1517 males and 1918 females).

[Significance of the individual helio-climatic factors in hemorrhagic fever with renal syndrome morbidity formation of population in the district of military units dislocation].

Been outlined the experience of mathematics modelling of natural phenomena for determination of the impact of individual factors and their combination on the epidemic process development. Found that 97,9% of the variation of haemorrhagic fever with renal syndrome index of population in the study area determine six climatic factors: the Wolf number, rainfall in November, the highest level of the river during floods, the temperature of air in October, the maximum and minimum levels of snow cover in February. As the most significant factors, contributing to the spread of the disease under study, been determine the parameters of air temperature and the height of snow.

[The cataract surgery survey in Slovakia, E.U., in 2008-2010].

Authors in retrospective study give the results of cataract surgery in Slovak Republic since 2008 to 2010. There are compiled results of the filled forms from all ophthalmology centers where cataract surgery were done, in this study.

Impact of perinatal photoperiod on the chronotype of 11- to 18-year-olds in northern European Russia.

The study investigates the effect of the month of birth and ambient light conditions at birth on sleep length and chronotype among residents of high latitudes. The authors surveyed 1172 persons (609 girls, 563 boys) age 11 to 18 yrs living in five villages and four towns located between 59.5°N and 67.

Chronotype, sleep length, and school achievement of 11- to 23-year-old students in northern European Russia.

Residing at northern latitudes for long periods of time is associated with sleep disturbances and internal desynchronization, which are considered to be causes of chronic diseases in old age. In children and teenagers, they result in a poor school achievement, psychological problems, and increase in consumption of stimulants. In this paper, we analyze the relationship between both chronotype and sleep length and the variables of age, sex, place of residence, type of settlement (village/city), latitude and longitude of residence, and school achievement of young inhabitants of northern European Russia.

[Influence of light and electromagnetic radiation of Sun on circadian rhythms of the total antioxidant capacity of human saliva in the North].

The literature and results of own researches concerning the influence of climatic conditions of the North on human organism are analyzed in the paper. Experimental and clinical data are in accordance with a hypothesis of "circadian destruction" covering the mechanism of negative influence of factors of the North on human health. The model to describe the possible mechanism of action of electromagnetic radiations on circadian system of an organism is offered.

[Prevalence of toxocariasis in rural and urban areas].

The prevalence of toxocariasis was studied among different age groups of the population in eight municipal entities of the Sverdlovsk Region. Since 1995, the number of infected patients was shown to have annually increased by 1.4-2 times and amounted to 2.

Production and purification of Japanese quail ovalbumin as fusion protein with glutathione S-transferase in Escherichia coli.

A plasmid encoding a fusion protein interlinked by thrombin recognition sequence between glutathione S-transferase and Japanese quail ovalbumin (without 40 amino acid residues from the 5'-end of the ORF) has been constructed, employing the expression system pGEX-2T. The deglycosylated fusion protein (64 kDa) was purified by affinity chromatography on glutathione agarose beads, analyzed by SDS-polyacrylamide gel electrophoresis, immunochemically detected with antiserum raised against Japanese quail ovalbumin and tested for its stability.